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Mutations of FLT3, ...
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia
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- Paulsson, Kajsa (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Department of Clinical Genetics, University Hospital, Lund, Sweden, Cancer Research UK Medical Oncology Centre, Barts and the London School of Medicine, Queen Mary College, London, United Kingdom
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- Horvat, A. (författare)
- Department of Clinical Genetics, University Hospital, Lund, Sweden
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- Strömbeck, Bodil (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Strömbeck, B., Department of Clinical Genetics, University Hospital, Lund, Sweden
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- Nilsson, F. (författare)
- Competence Center for Clinical Research, University Hospital, Lund, Sweden
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- Heldrup, Jesper (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Pediatrics, University Hospital, Lund, Sweden
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- Behrendtz, Mikael (författare)
- Östergötlands Läns Landsting,Barn- och ungdomskliniken i Linköping
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- Forestier, Erik (författare)
- Umeå universitet,Pediatrik,Department of Pediatrics, University Hospital, Umeå, Sweden
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- Andersson, Anna (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Department of Clinical Genetics, University Hospital, Lund, Sweden
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- Fioretos, Thoas (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Department of Clinical Genetics, University Hospital, Lund, Sweden
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- Johansson, Bertil (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Department of Clinical Genetics, University Hospital, Lund, Sweden, Department of Clinical Genetics, University Hospital, SE - 221 85 Lund, Sweden
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- Biloglav, Andrea (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- 2007
- 2008
- Engelska.
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Ingår i: Genes, Chromosomes and Cancer. - : Wiley. - 1045-2257 .- 1098-2264. ; 47:1, s. 26-33
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Although it has been suggested that mutations of the FLT3, NRAS, KRAS, and PTPN11 genes are particularly frequent in high hyperdiploid (>50 chromosomes) pediatric acute lymphoblastic leukemias (ALLs), this has as yet not been confirmed in a large patient cohort. Furthermore, it is unknown whether mutations of these genes coexist in hyperdiploid cases. We performed mutation analyses of FLT3, NRAS, KRAS, and PTPN11 in a consecutive series of 78 high hyperdiploid ALLs. Twenty-six (33%) of the cases harbored a mutation, comprising six activating point mutations and one internal tandem duplication of FLT3 (7/78 cases, 9.0%), eight codon 12, 13, or 61 NRAS mutations (8/78 cases, 10%), five codon 12 or 13 KRAS mutations (5/78 cases, 6.4%), and seven exon 3 or 13 PTPN11 mutations (7/78 cases, 9.0%). No association was seen between the presence of a mutation in FLT3, NRAS, KRAS, or PTPN11 and gender, age, white blood cell count, or relapse, suggesting that they do not confer a negative prognostic impact. Only one case harbored mutations in two different genes, suggesting that mutations of these four genes are generally mutually exclusive. In total, one third of the cases harbored a FLT3, NRAS, KRAS, or PTPN11 mutation, identifying the RTK-RAS signaling pathway as a potential target for novel therapies of high hyperdiploid pediatric ALLs. © 2007 Wiley-Liss, Inc.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- NATURAL SCIENCES
- NATURVETENSKAP
- Leukemia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Paulsson, Kajsa
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Horvat, A.
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Strömbeck, Bodil
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Nilsson, F.
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Heldrup, Jesper
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Behrendtz, Mikae ...
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visa fler...
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Forestier, Erik
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Andersson, Anna
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Fioretos, Thoas
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Johansson, Berti ...
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Biloglav, Andrea
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- Av lärosätet
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Linköpings universitet
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Umeå universitet
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Lunds universitet