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Clinical epidemiolo...
Clinical epidemiology of Guillain-Barré syndrome in adults in Sweden 1996-97 : A prospective study
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- Cheng, Q. (author)
- Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden, Division of Neurology, Huddinge University Hospital, S-141 86 Huddinge, Sweden
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- Jiang, G.-X. (author)
- Karolinska Institutet
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- Press, R. (author)
- Karolinska Institutet
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- Andersson, M. (author)
- Karolinska Institutet
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- Ekstedt, B. (author)
- Department of Neurology, Karolinska Hospital, Stockholm, Sweden
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- Vrethem, M. (author)
- Department of Neurology, Örebro Medical Centre Hospital, Sweden
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Liedholm, L.J. (author)
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- Lindsten, H. (author)
- Department of Neurology, Östersund Hospital, Östersund, Sweden
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- Brattstrom, L. (author)
- Brattström, L., Department of Neurology, University Hospital, Umeå, Sweden
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- Fredrikson, S. (author)
- Karolinska Institutet
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- Link, H. (author)
- Karolinska Institutet
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- De, Pedro-Cuesta J. (author)
- De Pedro-Cuesta, J., Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden, Department of Applied Epidemiology, National Centre for Epidemiology 'Carlos III', Institute of Health, Madrid, Spain
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(creator_code:org_t)
- Wiley, 2000
- 2000
- English.
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In: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 7:6, s. 685-692
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We described clinical manifestations, outcomes, prognostic indicators and clinico-epidemiological subgroups for 53 adult patients with Guillain-Barré syndrome (GBS) in Sweden during the period 1996-97. These patients were identified from a population of 2.8 million inhabitants and prospectively followed up for one year by a network of neurologists. An additional 10 cases, of whom five were adults who had not been prospectively followed up, were not included in the analyses. At 6 months after onset 80% of the patients could walk without aid, while at 1 year 46% were fully recovered, 42% had mild residual signs or symptoms, 4% had moderate and 6% severe disabilities, and 2% had died. Intravenous human immunoglobulin or plasmapheresis were used in 72% of the patients. The sum of the Medical Research Council (MRC) score at nadir was found as the only significant predictor for residual signs at 1 year in a multivariate model. Three subgroups, with different clinico-epidemiological characteristics, were identified by using cluster analysis. In conclusion, GBS in Sweden is frequently preceded by a respiratory infection, is often treated with immunomodulatory therapies, and exhibits a high recovery rate and a low fatality rate.
Keyword
- NATURAL SCIENCES
- NATURVETENSKAP
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Cheng, Q.
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Jiang, G.-X.
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Press, R.
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Andersson, M.
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Ekstedt, B.
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Vrethem, M.
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show more...
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Liedholm, L.J.
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Lindsten, H.
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Brattstrom, L.
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Fredrikson, S.
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Link, H.
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De, Pedro-Cuesta ...
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- Articles in the publication
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European Journal ...
- By the university
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Linköping University
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Karolinska Institutet