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Phase 2 study of al...
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Lundin, JKarolinska Institutet
(författare)
Phase 2 study of alemtuzumab (anti-CD52 monoclonal antibody) in patients with advanced mycosis fungoides/Sezary syndrome
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
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American Society of Hematology,2003
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-47796
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-47796URI
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https://doi.org/10.1182/blood-2002-09-2802DOI
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https://lup.lub.lu.se/record/310732URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1952232URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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This phase 2 study evaluated the safety and efficacy of alemtuzumab in 22 patients with advanced mycosis fungoides/Sezary syndrome (MF/SS). Most patients had stage III or IV disease, reduced performance status, and severe itching. The overall response (OR) rate was 55%, with 32% of patients in complete remission (CR) and M in, partial remission (PR). Sezary cells were cleared from the blood in 6 of 7 (86%) patients, and CR in lymph nodes was observed in 6 of 11 (55%) patients. The effect was better on erythro-derma (OR, 69%) than on plaque or skin tumors (OR, 40%) and in patients who had received 1 to 2 previous regimens (OR, 80%) thin in those who had received 3 or more prior regimens (OR, 33%). Itching, self-assessed on a 0 to 10 visual analog scale, was reduced from a median of 8 before treatment to 2 at end. of therapy. Median time to treatment failure was 12 months (range, 5-32+ months). Cytomegalovirus (CMV), reactivation (causing fever without pneumonitis and responding to ganciclovir) occurred in 4 (18%) patients. Six additional patients had suspect or manifest infection (fever of unknown origin, 3, generalized herpes simplex, 1, fatal aspergillosis, 1). One patient had fatal Mycobacterium pneumonia at 10+ months. All serious infectious adverse events (except CMV) occurred in patients who had received 3 or more prior regimens. Progression of squamous cell skin carcinoma was noted in 1 patient. Alemtuzumab shows promising clinical activity and an acceptable safety profile in patients with advanced MF/SS, particularly in patients with erythroderma and severe itching and those who were not heavily pretreated. (C) 2003 by The American Society of Hematology.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hagberg, H
(författare)
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Repp, R
(författare)
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Cavallin-Ståhl, EvaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ecs
(författare)
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Freden, S
(författare)
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Juliusson, GunnarÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Hematologiska kliniken US(Swepub:liu)gunju78
(författare)
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Rosenblad, E
(författare)
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Tjonnfjord, G
(författare)
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Wiklund, T
(författare)
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Osterborg, AKarolinska Institutet
(författare)
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Karolinska InstitutetBröstcancer-genetik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Blood: American Society of Hematology101:11, s. 4267-42720006-49711528-0020
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Blood
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Lundin, J
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Hagberg, H
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Repp, R
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Cavallin-Ståhl, ...
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Freden, S
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Juliusson, Gunna ...
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visa fler...
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Rosenblad, E
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Tjonnfjord, G
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Wiklund, T
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Osterborg, A
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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Blood
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Linköpings universitet
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Lunds universitet
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Karolinska Institutet