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Five-year follow-up...
Five-year follow-up on the PAT study : specific immunotherapy and long-term prevention of asthma in children
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- Niggemann, B. (författare)
- Department of Pediatric Pneumology and Immunology, Charité, Berlin, Germany, Department of Pediatric Pneumology and Immunology, University Children's Hospital Charité, Augustenburger Platz 1, 13353 Berlin, Germany
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- Jacobsen, L. (författare)
- ALK-Abelló, Hørsholm, Denmark
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- Dreborg, S. (författare)
- Department of Pediatrics, University Hospital of Oslo, Oslo, Norway
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- Ferdousi, Hosne Ara (författare)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Halken, S. (författare)
- Department of Pediatrics, Hospital of Sønderborg, Sønderborg, Denmark
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- Høst, A. (författare)
- Department of Pediatrics, University Hospital of Odense, Odense, Denmark
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- Koivikko, A. (författare)
- Turku Allergy Centre, Turku, Finland
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- Koller, D. (författare)
- Department of Pediatrics, University Hospital Vienna, Vienna, Austria
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- Norberg, L.A. (författare)
- Department of Pediatrics, University Hospital of Odense, Odense, Denmark
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- Urbanek, R. (författare)
- Department of Pediatrics, University Hospital Vienna, Vienna, Austria
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- Valovirta, E. (författare)
- Turku Allergy Centre, Turku, Finland
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- Wahn, U. (författare)
- Department of Pediatric Pneumology and Immunology, Charité, Berlin, Germany
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- Möller, C. (författare)
- Umeå universitet,Pediatrik,Department of Pediatrics, Umeå University, Umeå, Sweden
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(creator_code:org_t)
- Wiley, 2006
- 2006
- Engelska.
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 61:7, s. 855-859
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: A 3-year course of specific immunotherapy (SIT) in children with hay fever to grass and/or birch pollen significantly reduced the risk of developing asthma. To investigate the long-term preventive effect, we performed a follow up – 2 years after termination of immunotherapy.Methods: A total of 183 children, aged 6–14 years with grass and/or birch pollen allergy could be investigated 2 years after discontinuation of SIT or no treatment. Conjunctival provocation tests (CPTs) and methacholine bronchial provocation tests were carried out during the season and winter after 5 years. The development of asthma was assessed by clinical evaluation.Results: The significant improvement in hay fever and CPT results observed after 3 years of SIT persisted at the 5-year follow-up. No difference in bronchial responsiveness to methacholine was found after 5 years because of spontaneous improvement during the follow-up period in the control patients. The immunotherapy-treated children had significantly less asthma after 5 years as evaluated by clinical symptoms [odds ratio 2.68 (1.3–5.7)] in favor of SIT for prevention of development of asthma and significantly less patients reported an increase in asthma scores (P < 0.01).Conclusion: Immunotherapy for 3 years with standardized allergen extracts of grass and/or birch shows long-term clinical effect and preventive effect on development of asthma in children with seasonal rhinoconjunctivitis.
Nyckelord
- Asthma
- Bronchial hyperresponsiveness
- Long-term effect
- Prevention
- Rhinitis
- Specific immunotherapy
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Niggemann, B.
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Jacobsen, L.
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Dreborg, S.
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Ferdousi, Hosne ...
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Halken, S.
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Høst, A.
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visa fler...
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Koivikko, A.
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Koller, D.
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Norberg, L.A.
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Urbanek, R.
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Valovirta, E.
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Wahn, U.
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Möller, C.
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- Artiklar i publikationen
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Allergy. Europea ...
- Av lärosätet
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Linköpings universitet
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Umeå universitet