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Effects of weaning ...
Effects of weaning cereals with different phytate contents on hemoglobin, iron stores, and serum zinc: a randomized intervention in infants from 6 to 12 mo of age
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- Lind, Torbjörn (författare)
- Umeå University
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- Lonnerdal, Bo (författare)
- University of California
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- Persson, Lars-Åke (författare)
- Umeå University
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- Stenlund, Hans (författare)
- Umeå University
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- Tennefors, Catharina (författare)
- Linköpings universitet,Institutionen för biomedicin och kirurgi,Hälsouniversitetet
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- Hernell, Olle (författare)
- Umeå University
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: American Journal of Clinical Nutrition. - 0002-9165 .- 1938-3207. ; 78:1, s. 168-175
- Relaterad länk:
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http://www.ajcn.org/...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Weaning foods frequently contain phytate, an inhibitor of iron and zinc absorption, which may contribute to the high prevalence of iron and zinc deficiency seen in infancy. Objective: The objective was to investigate whether either an extensive reduction in the phytate content of infant cereals or the use of milk-based, iron-fortified infant formula would improve iron and zinc status in infants. Design: In a double-blind design, infants (n = 300) were randomly assigned to 3 cereal groups from 6 to 12 mo of age: commercial milk-based cereal drink (MCD) and porridge (CC group), phytate-reduced MCD and phytate-reduced porridge (PR group), or milk-based infant formula and porridge with the usual phytate content (IF group). Venous blood samples were collected at 6 and 12 mo. Dietary intake was recorded monthly. After the intervention, 267 infants remained in the analysis. Results: Hemoglobin concentrations of less than 110 g/L, serum ferritin concentrations of less than 12 mug/L, and serum zinc concentrations of less than 10.7 mumol/L had overall prevalences at baseline and 12 mo of 28% and 15%, 9% and 18%, and 22% and 27%, respectively. After the intervention, there were no significant differences in any measure of iron or zinc status between the CC and the PR groups. However, hemoglobin was significantly higher (120 g/L compared with 117 g/L; P = 0.012) and the prevalence of anemia was lower (13% compared with 23%; P = 0.06) in the PR group than in the IF group, which could be explained by differences in daily iron intake between the 2 groups. Conclusion: Extensive reduction in the phytate content of weaning cereals had little long-term effect on the iron and zinc status of Swedish infants.
Nyckelord
- infants; cereals; iron; zinc; phytate; randomized controlled trial; weaning; Sweden
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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