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Hypoproteinemia doe...
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Brauer, Kirk IUniversity of Texas Medical Branch
(författare)
Hypoproteinemia does not alter plasma volume expansion in response to a 0.9% saline bolus in awake sheep
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Williams and Wilkins,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-60253
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-60253URI
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https://doi.org/10.1097/CCM.0b013e3181ef45e2DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121290889URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective: To test the hypothesis that hypoproteinemia reduces plasma volume expansion produced by a bolus of crystalloid solution given to awake sheep. Design: Prospective and observational. Setting: Laboratory. Subjects: Five female merino sheep (n = 5) weighing 37 +/- 3 kg were anesthetized. Interventions: Each animal was subjected to a 5-day test period: day 1: 50 mL/min 0.9% saline infusion over 20 mins. Days 2-4: daily plasmapheresis and replacement of the shed plasma with 6 L of 0.9% saline were performed in increments. Measurements and Main Results: Fractional plasma volume expansion after rapid infusion of saline on days 1 and 5 was calculated from changes in hemoglobin concentration. There was a significant reduction in total plasma protein concentration after plasmapheresis (p andlt; .05). Colloid osmotic pressures were also significantly lowered (p andlt; .05). A crystalloid infusion of 0.9% saline did not alter any of these values compared with baseline. The hemodynamic measurements did not show significant differences between the experiments. The plasma volume expansion reached approximately 20% at the end of infusion and stayed at 10-15% during the experiments. No difference was found in plasma volume expansion produced by a bolus of 50 mL/min of 0.9% in the hypoproteinemic state when compared with the euproteinemic state (p = .61). No difference in cumulative urinary output was found between the two states. Conclusions: In contrast to our hypothesis, severe acute hypoproteinemia does not reduce plasma volume expansion in response to 50 mL/min 0.9% saline infusion in nonspleenectomized sheep when compared with the resultant plasma volume expansion after a 50 mL/min of 0.9% infusion in the euproteinemic state.
Ämnesord och genrebeteckningar
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anesthesia
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hypoproteinemia
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plasma volume expansion
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crystalloids
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fluid distribution
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Brauer, Lance PUniversity of Texas Medical Branch
(författare)
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Prough, Donald SUniversity of Texas Medical Branch
(författare)
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Rodhe, PeterKarolinska Institute
(författare)
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Hahn, Robert GKarolinska Institutet,Östergötlands Läns Landsting,Linköpings universitet,Anestesiologi med intensivvård,Hälsouniversitetet,Anestesi- och operationkliniken US(Swepub:liu)robha40
(författare)
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Traber, Daniel LUniversity of Texas Medical Branch
(författare)
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Traber, Lilian DUniversity of Texas Medical Branch
(författare)
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Svensen, Christer HKarolinska Institutet
(författare)
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University of Texas Medical BranchKarolinska Institute
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:CRITICAL CARE MEDICINE: Williams and Wilkins38:10, s. 2011-20150090-34931530-0293
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