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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03891naa a2200457 4500 | |
| 001 | oai:DiVA.org:liu-60253 | |
| 003 | SwePub | |
| 008 | 101008s2010 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:121290889 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-602532 URI |
| 024 | 7 | a https://doi.org/10.1097/CCM.0b013e3181ef45e22 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1212908892 URI |
| 040 | a (SwePub)liud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Brauer, Kirk Iu University of Texas Medical Branch4 aut |
| 245 | 1 0 | a Hypoproteinemia does not alter plasma volume expansion in response to a 0.9% saline bolus in awake sheep |
| 264 | 1 | b Williams and Wilkins,c 2010 |
| 338 | a print2 rdacarrier | |
| 520 | a Objective: To test the hypothesis that hypoproteinemia reduces plasma volume expansion produced by a bolus of crystalloid solution given to awake sheep. Design: Prospective and observational. Setting: Laboratory. Subjects: Five female merino sheep (n = 5) weighing 37 +/- 3 kg were anesthetized. Interventions: Each animal was subjected to a 5-day test period: day 1: 50 mL/min 0.9% saline infusion over 20 mins. Days 2-4: daily plasmapheresis and replacement of the shed plasma with 6 L of 0.9% saline were performed in increments. Measurements and Main Results: Fractional plasma volume expansion after rapid infusion of saline on days 1 and 5 was calculated from changes in hemoglobin concentration. There was a significant reduction in total plasma protein concentration after plasmapheresis (p andlt; .05). Colloid osmotic pressures were also significantly lowered (p andlt; .05). A crystalloid infusion of 0.9% saline did not alter any of these values compared with baseline. The hemodynamic measurements did not show significant differences between the experiments. The plasma volume expansion reached approximately 20% at the end of infusion and stayed at 10-15% during the experiments. No difference was found in plasma volume expansion produced by a bolus of 50 mL/min of 0.9% in the hypoproteinemic state when compared with the euproteinemic state (p = .61). No difference in cumulative urinary output was found between the two states. Conclusions: In contrast to our hypothesis, severe acute hypoproteinemia does not reduce plasma volume expansion in response to 50 mL/min 0.9% saline infusion in nonspleenectomized sheep when compared with the resultant plasma volume expansion after a 50 mL/min of 0.9% infusion in the euproteinemic state. | |
| 653 | a anesthesia | |
| 653 | a hypoproteinemia | |
| 653 | a plasma volume expansion | |
| 653 | a crystalloids | |
| 653 | a fluid distribution | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Brauer, Lance Pu University of Texas Medical Branch4 aut |
| 700 | 1 | a Prough, Donald Su University of Texas Medical Branch4 aut |
| 700 | 1 | a Rodhe, Peteru Karolinska Institute4 aut |
| 700 | 1 | a Hahn, Robert Gu Karolinska Institutet,Östergötlands Läns Landsting,Linköpings universitet,Anestesiologi med intensivvård,Hälsouniversitetet,Anestesi- och operationkliniken US4 aut0 (Swepub:liu)robha40 |
| 700 | 1 | a Traber, Daniel Lu University of Texas Medical Branch4 aut |
| 700 | 1 | a Traber, Lilian Du University of Texas Medical Branch4 aut |
| 700 | 1 | a Svensen, Christer Hu Karolinska Institutet4 aut |
| 710 | 2 | a University of Texas Medical Branchb Karolinska Institute4 org |
| 773 | 0 | t CRITICAL CARE MEDICINEd : Williams and Wilkinsg 38:10, s. 2011-2015q 38:10<2011-2015x 0090-3493x 1530-0293 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-60253 |
| 856 | 4 8 | u https://doi.org/10.1097/CCM.0b013e3181ef45e2 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:121290889 |
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