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Maternal serum conc...
Maternal serum concentrations of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to maternal body weight and composition and infant birth weight
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- Olausson, Hanna (författare)
- Gothenburg University,Göteborgs universitet,Linköpings universitet,Näringslära,Hälsouniversitetet,Institutionen för medicin, avdelningen för klinisk näringslära,Institute of Medicine, Department of Clinical Nutrition
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- Löf, Marie (författare)
- Karolinska Institutet,Linköpings universitet,Näringslära,Hälsouniversitetet
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- Brismar, Kerstin (författare)
- Karolinska Institutet
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- Forsum, Elisabet (författare)
- Linköpings universitet,Näringslära,Hälsouniversitetet
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- Sohlström, Annica (författare)
- Linköpings universitet,Näringslära,Hälsouniversitetet
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(creator_code:org_t)
- Cambridge University Press, 2010
- 2010
- Engelska.
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Ingår i: British Journal of Nutrition. - : Cambridge University Press. - 0007-1145 .- 1475-2662. ; 104:6, s. 842-848
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Maternal nutritional status, e.g. body weight and composition, is associated with fetal growth. It has been suggested that the insulin-like growth factor (IGF) system may be a mediator of this relationship. In twenty-three healthy Swedish women, we studied (1) the relationships before and during pregnancy between maternal serum concentrations of IGF-I and IGF binding protein-1 (IGFBP-1) and maternal body weight and composition; (2) interactions between serum concentrations of IGF-I (before and in early pregnancy) and maternal nutritional status in relation to infant birth weight. We found that serum IGF-I during pregnancy was positively correlated with maternal body weight (r 0·47–0·56) and fat-free body weight (r 0·61–0·65), whereas serum IGFBP-1 was negatively correlated with maternal body weight (r − 0·44 to − 0·69) and body fat (r − 0·64 to − 0·76) before and during pregnancy. Women with a lower body fat content (%) before pregnancy had greater increases in serum IGFBP-1 during pregnancy than women with a higher prepregnant body fat content (%). In addition, significant fractions of the variation in corrected infant birth weight were explained by variables related to the maternal nutritional status when these were combined with serum concentrations of IGF-I in gestational week 14 (adjusted r2 0·25–0·44, P = 0·001–0·021), but not when they were combined with such concentrations before pregnancy (adjusted r2 0·11–0·12, P = 0·105–0·121). These results suggest mechanisms by which the IGF system may be a mediator between maternal nutritional status and fetal growth.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Insulin-like growth factor-I
- Insulin-like growth factor binding protein-1
- Body fat
- Fat-free body weight
- Infant birth weight
- MEDICINE
- MEDICIN
- Insulin-like growth factor-I; Insulin-like growth factor binding protein-1; Body fat; Fat-free body weight; Infant birth weight
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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