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Long-term survival ...
Long-term survival according to ventilation mode in acute respiratory failure secondary to chronic obstructive pulmonary disease: A multicenter, inception cohort study
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- Berkius, Johan (författare)
- Linköpings universitet,Kardiologi,Hälsouniversitetet,Department of Anesthesia and Intensive Care, Västervik Hospital, Västervik, Sweden; Division of Cardiovascular Medicine, Faculty of Health Sciences, Department of Medicine and Health Sciences, Linköping University, Linköping, Sweden
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- Sundh, Josefin, 1972- (författare)
- Department of Pulmonary Medicine, Örebro University Hospital, Örebro, Sweden
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- Nilholm, Lennart (författare)
- Department of Pulmonary Medicine, Örebro University Hospital, Örebro, Sweden
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- Fredrikson, Mats (författare)
- Linköpings universitet,Yrkes- och miljömedicin,Hälsouniversitetet,Division of Occupational and Environmental Sciences, Department of Clinical and Experimental Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Walther, Sten (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Fysiologi,Hälsouniversitetet,Thorax-kärlkliniken,Division of Cardiovascular Medicine, Faculty of Health Sciences, Department of Medicine and Health Sciences, Linköping University, Linköping, Sweden; Department of Cardiothoracic Anesthesia and Intensive Care, University Hospital, Linköping, Sweden
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(creator_code:org_t)
- Elsevier Science B. V., Amsterdam, 2010
- 2010
- Engelska.
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Ingår i: JOURNAL OF CRITICAL CARE. - : Elsevier Science B. V., Amsterdam. - 0883-9441 .- 1557-8615. ; 25:3
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Purpose: The aim of the study was to investigate 5-year survival stratified by mechanical ventilation modality in chronic obstructive pulmonary disease (COPD) patients treated in the ICU. Materials and Methods: Prospective, observational study of COPD patients with acute respiratory failure admitted to 9 multidisciplinary ICUs in Sweden. Characteristics on admission, including illness severity scores and the first blood gas, and survival were analyzed stratified by ventilation modality (noninvasive [NIV] vs invasive mechanical ventilation). Results: Ninety-three patients, mean age of 70.6 (SD, 9.6) years, were included. Sixteen patients were intubated immediately, whereas 77 were started on NIV. Patients who were started on NIV had a lower median body mass index (BMI) (21.9 vs 27.0; P andlt; .01) and were younger compared to those who were intubated immediately (median age, 70 vs 74.5 years; P andlt; .05). There were no differences in the initial blood gas results between the groups. Long-term survival was greater in patients with NIV (P andlt; .05, log rank). The effect of NIV on survival remained after including age, Acute Physiology and Chronic Health Evaluation II score, and BMI in a multivariate Cox regression model (NIV hazard ratio, 0.44; 95% confidence interval, 0.21-0.92). Fifteen patients with failed NIV were intubated and mechanically ventilated. Long-term survival in patients with failed NIV was not significantly different from patients who were intubated immediately. Conclusion: The short-term survival benefit of NIV previously found in randomized controlled trials still applies after 5 years of observation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Intensive care
- Mechanical ventilation
- Noninvasive ventilation
- Endotracheal intubation
- Long-term outcome
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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