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Weight gain by hype...
Weight gain by hyperalimentation elevates C-reactive protein levels but does not affect circulating levels of adiponectin or resistin in healthy subjects
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- Åstrand, Olov (författare)
- Linköpings universitet,Institutionen för medicin och hälsa,Hälsouniversitetet
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- Carlsson, Martin (författare)
- Länssjukhuset i Kalmar
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- Nilsson, Ingela (författare)
- Länssjukhuset i Kalmar
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- Lindström, Torbjörn (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet
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- Borga, Magnus (författare)
- Linköpings universitet,Medicinsk informatik,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Tekniska högskolan
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- Nyström, Fredrik (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet
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(creator_code:org_t)
- Bristol : BioScientifica, 2010
- 2010
- Engelska.
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Ingår i: European Journal of Endocrinology. - Bristol : BioScientifica. - 0804-4643 .- 1479-683X. ; 163:6, s. 879-885
- Relaterad länk:
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http://www.eje-onlin...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Increase of resistin and/or reduction of adiponectin have beenimplicated in the development of insulin resistance followingweight gain. We aimed to study this prospectively in humans.Design: Prospective and interventional with parallel control group.Methods: Twelve healthy men and six healthy women (age 26±6.6years) and an age-matched control group were recruited. Subjectsin the intervention group aimed for a bodyweight increase of5–15% by doubling the baseline caloric intake by eatingat least two fast food-based meals a day in combination withadoption of a sedentary lifestyle for 4 weeks.Results: Bodyweight increased from 67.6±9.1 to 74.0±11kg, P<0.001, by the intervention. Insulin levels increased(before: 27.4±12 pmol/l, after: 53.0±22 pmol/l,P=0.004), while plasma levels of adiponectin (before: 5038±3736ng/ml, after: 6739±7949 ng/ml, P=0.18) and resistin (before:21.8±19 ng/ml, after: 14.4±6.8 ng/ml, P=0.074)remained unchanged by the weight gain and were similar as incontrols. On the other hand, leptin levels increased about threefoldfollowing the intervention (before: 5.7±7.4, after: 16±20ng/ml, P=0.008), and also the inflammatory marker C-reactiveprotein (CRP) increased from 0.34±0.44 to 0.71±0.87mg/l, P=0.03, when two outliers >10 mg/l were disregarded.Conclusions: Hyperalimentation reduces insulin sensitivity when weight gainof 9% was combined with reduction of exercise. However, thelevels of resistin and adiponectin were unaffected by the intervention,while CRP levels increased within this short time period suggestingthat low-grade inflammation can occur early in the process ofdeveloping a metabolic syndrome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Endocrinology
- Endokrinologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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