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Downregulation of c...
Downregulation of caspase-9 is a frequent event in patients with stage II colorectal cancer and correlates with poor clinical outcome
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- Shen, X-G (författare)
- Sichuan University
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- Wang, C (författare)
- Sichuan University
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- Li, Y (författare)
- Sichuan University
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- Wang, L (författare)
- Sichuan University
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- Zhou, B (författare)
- Sichuan University
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- Xu, B (författare)
- Sichuan University
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- Jiang, X (författare)
- Sichuan University
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- Zhou, Z-G (författare)
- Sichuan University
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- Sun, Xiao-Feng (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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(creator_code:org_t)
- 2010-11-11
- 2010
- Engelska.
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Ingår i: COLORECTAL DISEASE. - : Blackwell Publishing Ltd. - 1462-8910. ; 12:12, s. 1213-1218
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective To evaluate the clinical significance of caspase-9 mRNA expression and investigate its prognostic value in stage II colorectal cancer. Method Quantitative real-time RT-PCR was used to analyse caspase-9 mRNA expression in cancer tissue and corresponding normal mucosa from 120 patients. Results Compared with normal mucosa, the expression of caspase-9 mRNA was found to be downregulated in cancer tissue (P = 0.001). Poorly differentiated cancer showed lower mRNA expression than cancer with greater differentiation (P = 0.031). The Kaplan-Meier survival analysis demonstrated that patients with downregulated caspase-9 showed a worse overall survival (P = 0.012) and disease-free survival (P = 0.022). Coxs proportional hazards regression model confirmed that expression of caspase-9 was the strongest prognostic factor in stage II colorectal cancer. Conclusion The mRNA expression of caspase-9 can be used as an independent prognostic factor for patients with stage II colorectal cancer.
Nyckelord
- Stage II
- colorectal cancer
- caspase-9
- apoptosis
- prognostic factor
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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