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Hyperaemic changes ...
Hyperaemic changes in forearm skin perfusion and RBC concentration after increasing occlusion times
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- Farnebo, Simon (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kirurgi,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken US
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- Thorfinn, Johan (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kirurgi,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken US
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- Henricson, Joakim (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Tesselaar, Erik (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier Science B.V., Amsterdam, 2010
- 2010
- Engelska.
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Ingår i: MICROVASCULAR RESEARCH. - : Elsevier Science B.V., Amsterdam. - 0026-2862. ; 80:3, s. 412-416
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Tissue occlusion and the hyperaemic response upon reperfusion can be used as a tool to assess microvascular function in various vascular diseases. Currently, laser Doppler flowmetry (LDF) is applied most often to measure hyperaemic responses. In this study, we have applied tissue viability imaging (TiVi) and LDF to measure the change in red blood cell concentration and perfusion in the skin after occlusions of the forearm with increasing duration. We have found that there is a strong correlation between the changes in perfusion and red blood cell (RBC) concentration during post-occlusive hyperaemia (perfusion: r = 0.80; RBC concentration: r = 0.94). This correlation increases with longer occlusion durations (1, 5 and 10 min). Furthermore, for both perfusion and RBC concentration, the maximum responses (perfusion: r(2) = 0.59; RBC concentration: r(2) = 0.78) and the recovery times (perfusion: r(2) = 0.62; RBC concentration: r(2) = 0.91) increase linearly with the duration of the occlusion. Maximum responses and recovery times were more reproducible for RBC concentration (as measured with TiVi) than for perfusion (as measured with LDF). These results show that perfusion and RBC concentration are related during post-occlusive hyperaemia and that TiVi can be used as a tool in the assessment of hyperaemic responses that has advantages in terms of reproducibility, sensitivity and ease of use.
Nyckelord
- Occlusion
- Hyperaemia
- Laser Doppler
- Tissue viability imaging
- Perfusion
- Red blood cell concentration
- Polarisation light spectroscopy
- Ischemia
- Reperfusion
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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