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Elevated levels of ...
Elevated levels of circulating matrix metalloproteinase-9 are associated with a dysregulated cortisol rhythm-A case-control study of coronary artery disease
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- Szymanowski, A (författare)
- County Hospital Ryhov
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- Kristenson, Margareta (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Socialmedicin och folkhälsovetenskap,Hälsouniversitetet,Folkhälsovetenskapligt centrum
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- Jonasson, Lena (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken
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(creator_code:org_t)
- Elsevier Science B.V., Amsterdam. 2011
- 2011
- Engelska.
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Ingår i: PSYCHONEUROENDOCRINOLOGY. - : Elsevier Science B.V., Amsterdam.. - 0306-4530. ; 36:1, s. 139-143
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A dysregulated cortisol pattern has been found to be associated with systemic inflammatory activity in patients with coronary artery disease (CAD). Matrix metalloproteinase (MMP)-9 is involved in both inflammation and matrix degradation and considered a main contributor to coronary plaque rupture. In this study, we hypothesized that a dysfunctional cortisol response also involved a failure to regulate systemic MMP-9 levels in CAD patients. Total MMP-9, active MMP-9 and the endogenous inhibitor TIMP-1 were measured in 30 CAD patients and 30 healthy controls. Morning and evening cortisol was measured in repeated saliva samples. Patients had higher levels of total and active MMP-9 (both p andlt; 0.01) and increased 24-h cortisol output (p andlt; 0.05) characterized by higher levels of evening cortisol (p = 0.011). MMP-9 was associated with evening cortisol (p andlt; 0.001) independent of smoking and inflammatory markers. Compared with controls, patients also showed a blunted cortisol response to stress. After stress, the levels of MMP-9 became significantly reduced in controls whereas they remained unchanged in patients. The data indicate that MMP-9 is differently regulated in patients due to a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis and emphasize the role of MMP-9 as a possible link between stress and cardiovascular disease.
Nyckelord
- Matrix metalloproteinase
- Coronary artery disease
- Cortisol
- Stress
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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