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Effects of intracer...
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Holm, LovisaLinköpings universitet,Klinisk kemi,Hälsouniversitetet
(författare)
Effects of intracerebroventricular galanin or a galanin receptor 2/3 agonist on the lesion induced by transient occlusion of the middle cerebral artery in female rats
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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Elsevier Science B.V., Amsterdam,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-66126
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66126URI
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https://doi.org/10.1016/j.npep.2010.09.002DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121953758URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Several studies have shown that injury to the central and peripheral nervous system can increase expression of galanin, a 29 amino acid neuropeptide. Moreover, there is evidence that galanin, especially through its galanin receptor 2 (GalR2) receptor, plays a neuroprotective role in different injury models. However, direct studies of a possible neuroprotective effect of galanin in experimental stroke models are lacking. Galanin, a GalR2/3 agonist or artificial CSF was continuously infused intracerebroventricularly (i.c.v.) in naive female rats after a 60 min transient and focal occlusion of the middle cerebral artery. The animals were sacrificed, and the ischemic lesion was visualized using 2,3,5-triphenyltetrazolium hydrochloride (TTC) staining. The lesion was 98% larger after i.c.v, administration of the GalR2/3 agonist (2.4 nmol/day) seven days after occlusion compared to artificial CSF (p = 0.023). No statistically significant differences were found after seven days in the groups treated with galanin in three different concentrations (0.24, 2.4 and 24 nmol/day; p = 0.939, 0.715 and 0.977, respectively). There was no difference in the size of the ischemic lesions measured after three days in the galanin-treated group (2.4 nmol/d) compared to artificial CSF (p = 0.925). The present results show, surprisingly, that a GalR2/3 agonist doubled the size of the ischemic lesion. Whether this effect primarily reflects the properties of the current model, species, gender and/or the mode of galanin administration, e.g. causing desensitization, or whether galanin indeed lacks neuroprotective effect of its own, remains to be corroborated.
Ämnesord och genrebeteckningar
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Cerebral ischemia
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Neuropeptide
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Neuroprotection
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Stroke
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Theodorsson, ElvarÖstergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)elvth65
(författare)
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Hokfelt, TomasKarolinska Institutet
(författare)
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Theodorsson, AnnetteÖstergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet,Neurokirurgiska kliniken US(Swepub:liu)annth93
(författare)
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Linköpings universitetKlinisk kemi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neuropeptides: Elsevier Science B.V., Amsterdam45:1, s. 17-230143-41791532-2785
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