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Differences in inna...
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Tulic, Meri KUniversity of Western Australia
(författare)
Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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Elsevier Science B.V., Amsterdam,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-66292
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66292URI
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https://doi.org/10.1016/j.jaci.2010.09.020DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Microbial products are of central interest in the modulation of allergic propensity. Objective: We sought to explore whether allergic children show differences in microbial Toll-like receptor (TLR)-mediated responses over their first 5 years of life. Methods: Mononuclear cells isolated from 35 allergic and 35 nonallergic children at birth and 1, 2.5, and 5 years of age were stimulated with TLR2-TLR9 ligands to study innate immune function and with allergens or mitogen to assess adaptive T-cell responses. Cytokine production was measured by using Luminex multiplexing technology. Results: Nonallergic children show progressive and significant age-related increases in innate cytokine responses (IL-1 beta, IL-6, TNF-alpha, and IL-10) to virtually all TLR ligands. This innate maturation corresponds with a parallel increase in adaptive T(H)1 (IFN-gamma) responses to allergens and mitogens. In contrast, allergic children show exaggerated innate responses at birth (P andlt; .01) but a relative decrease with age thereafter, so that by age 5 years, TLR responses are attenuated compared with those seen in nonallergic subjects (P andlt; .05). This early hyperresponsiveness in allergic subjects fails to translate to a corresponding maturation of T(H)1 function, which remains attenuated relative to that seen in nonallergic subjects but is associated with a characteristic age-dependent increase in allergen-specific T(H)2 responses (P andlt; .01). Conclusion: Our findings suggest significant differences in the developmental trajectory of innate immune function in children with allergic disease that might contribute to the recognized differences in postnatal adaptive T-cell immunity.
Ämnesord och genrebeteckningar
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Toll-like receptor
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ontogeny
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innate immunity
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allergic disease
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children
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TECHNOLOGY
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TEKNIKVETENSKAP
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hodder, MeganLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
(författare)
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McCarthy, SuziUWA
(författare)
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A Thornton, CatherineSwansea University
(författare)
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Prescott, Susan LUniversity of Western Australia
(författare)
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University of Western AustraliaInstitutionen för klinisk och experimentell medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: Elsevier Science B.V., Amsterdam127:2, s. 470-U18170091-6749
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