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Increased Levels of...
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Linderholm, Klas RDepartment of Physiology and Pharmacology, Karolinska Institutet
(författare)
Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2010-08-20
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Oxford University Press,2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-66972
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66972URI
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https://doi.org/10.1093/schbul/sbq086DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124517087URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-174716URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients. KYNA is an endogenous metabolite of tryptophan (TRP) produced in astrocytes and antagonizes N-methyl-D-aspartate and alpha7* nicotinic receptors. Methods: The formation of KYNA is determined by the availability of substrate, and hence, we analyzed KYNA and its precursors, kynurenine (KYN) and TRP, in the cerebrospinal fluid (CSF) of patients with schizophrenia. CSF from male patients with schizophrenia on olanzapine treatment (n = 16) was compared with healthy male volunteers (n = 29). Results: KYN and KYNA concentrations were higher in patients with schizophrenia (60.7 +/- 4.37nM and 2.03 +/- 0.23nM, respectively) compared with healthy volunteers (28.6 +/- 1.44nM and 1.36 +/- 0.08nM, respectively), whereas TRP did not differ between the groups. In all subjects, KYN positively correlated to KYNA. Conclusion: Our results demonstrate increased levels of CSF KYN and KYNA in patients with schizophrenia and further support the hypothesis that KYNA is involved in the pathophysiology of schizophrenia.
Ämnesord och genrebeteckningar
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psychosis
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kynurenate
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olanzapine
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cerebrospinal fluid
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tryptophan
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Skogh, ElisabethÖstergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken(Swepub:liu)elisk66
(författare)
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Olsson, Sara KDepartment of Physiology and Pharmacology, Karolinska Institutet
(författare)
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Dahl, Marja-LiisaUppsala universitet,Karolinska Institutet,Department of Medical Sciences, Clinical Pharmacology, Uppsala University,Institutionen för medicinska vetenskaper(Swepub:uu)madah516
(författare)
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Holtze, MariaDepartment of Physiology and Pharmacology, Karolinska Institutet
(författare)
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Engberg, GöranKarolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet
(författare)
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Samuelsson, MartinÖstergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken(Swepub:liu)marsa78
(författare)
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Erhardt, SophieKarolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet
(författare)
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Department of Physiology and Pharmacology, Karolinska InstitutetPsykiatri
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Schizophrenia Bulletin: Oxford University Press38:3, s. 426-4320586-76141745-1701
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