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Urine C-Peptide Cre...
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Besser, Rachel E JUniversity of Exeter
(författare)
Urine C-Peptide Creatinine Ratio Is a Noninvasive Alternative to the Mixed-Meal Tolerance Test in Children and Adults With Type 1 Diabetes
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2011-02-17
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American Diabetes Association Inc,2011
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-67027
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-67027URI
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https://doi.org/10.2337/dc10-2114DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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OBJECTIVE-Stimulated serum C-peptide (sCP) during a mixed-meal tolerance test (MMTT) is the gold standard measure of endogenous insulin secretion, but practical issues limit its use. We assessed urine C-peptide creatinine ratio (UCPCR) as an alternative. RESEARCH DESIGN AND METHODS-Seventy-two type 1 diabetic patients (age of diagnosis median 14 years [interquartile range 10-22]; diabetes duration 6.5[2.3-32.7]) had an MMTT. sCP was collected at 90 min. Urine for UCPCR was collected at 120 min and following a home evening meal. RESULTS-MMTT 120-min UCPCR was highly correlated to 90-min sCP (r = 0.97; P andlt; 0.0001). UCPCR andgt;= 0.53 nmol/mmol had 94% sensitivity/100% specificity for significant endogenous insulin secretion (90-min sCP andgt;= 0.2 nmol/L). The 120-min postprandial evening meal UCPCR was highly correlated to 90-min sCP (r = 0.91; P andlt; 0.0001). UCPCR andgt;= 0.37 nmol/mmol had 84% sensitivity/97% specificity for sCP andgt;= 0.2 nmol/L. CONCLUSIONS-UCPCR testing is a sensitive and specific method for detecting insulin secretion. UCPCR may be a practical alternative to serum C-peptide testing, avoiding the need for inpatient investigation.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29
(författare)
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Jones, Angus GUniversity of Exeter
(författare)
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McDonald, Timothy JUniversity of Exeter
(författare)
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Shields, Beverley MUniversity of Exeter
(författare)
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Knight, Bridget AUniversity of Exeter
(författare)
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Hattersley, Andrew TUniversity of Exeter
(författare)
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University of ExeterPediatrik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:DIABETES CARE: American Diabetes Association Inc34:3, s. 607-6090149-59921935-5548
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