Sökning: onr:"swepub:oai:DiVA.org:liu-67325" >
Feasibility and com...
Feasibility and compliance in a nutritional primary prevention trial in infants at increased risk for type 1 diabetes
-
- Virtanen, S M (författare)
- National Institute of Health and Welfare, Helsinki
-
- Barlund, S (författare)
- National Institute of Health and Welfare, Helsinki
-
- Salonen, M (författare)
- University of Helsinki
-
visa fler...
-
- Savilahti, E (författare)
- University of Helsinki
-
- Reunanen, A (författare)
- National Institute of Health and Welfare, Helsinki
-
- Paronen, J (författare)
- University of Helsinki
-
- Hamalainen, A-M (författare)
- Jorvi Hospital
-
- Ilonen, J (författare)
- University of Eastern Finland
-
- Teramo, K (författare)
- University of Helsinki
-
- Erkkola, M (författare)
- National Institute of Health and Welfare, Helsinki
-
- Ormisson, A (författare)
- University of Tartu
-
- Einberg, U (författare)
- Tallinn Childrens Hospital
-
- Riikjarv, M-A (författare)
- Tallinn Childrens Hospital
-
- Ludvigsson, Johnny (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
-
- Knip, M (författare)
- University of Helsinki
-
- Akerblom, H K (författare)
- University of Helsinki
-
visa färre...
-
(creator_code:org_t)
- 2011-01-10
- 2011
- Engelska.
-
Ingår i: ACTA PAEDIATRICA. - : Blackwell Publishing Ltd. - 0803-5253. ; 100:4, s. 557-564
- Relaterad länk:
-
https://europepmc.or...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aim: The international Trial to Reduce IDDM in the Genetically at Risk (TRIGR) was launched to determine whether weaning to a highly hydrolysed formula in infancy reduces the incidence of type 1 diabetes in children at increased genetic disease susceptibility. We describe here the findings on feasibility and compliance from the pilot study. Methods: The protocol was tested in 240 children. The diet of the participating children was assessed by self-administered dietary forms, a structured questionnaire and a food record. Blood samples were taken and weight and height measured at birth and at 3, 6, 9, 12, 18 and 24 months. Results: A majority of the subjects (84%) were exposed to the study formula at least for 2 months. Linear growth or weight gain over the first 2 years of life was similar in the two study groups. The levels of IgA and IgG antibodies to cows milk and casein were higher in the cows milk-based formula group than in the hydrolysed formula group during the intervention period (p andlt; 0.05), reflecting the difference in the intake of cows milk protein. Conclusion: This randomized trial on infant feeding turned out to be feasible, and dietary compliance was acceptable. Valuable experience was gained for the planning and sample size estimation of the study proper.
Nyckelord
- Compliance
- Feasibility
- Hydrolysed infant formula
- Infants
- Primary prevention
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Virtanen, S M
-
Barlund, S
-
Salonen, M
-
Savilahti, E
-
Reunanen, A
-
Paronen, J
-
visa fler...
-
Hamalainen, A-M
-
Ilonen, J
-
Teramo, K
-
Erkkola, M
-
Ormisson, A
-
Einberg, U
-
Riikjarv, M-A
-
Ludvigsson, John ...
-
Knip, M
-
Akerblom, H K
-
visa färre...
- Artiklar i publikationen
-
ACTA PAEDIATRICA
- Av lärosätet
-
Linköpings universitet