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Sökning: onr:"swepub:oai:DiVA.org:liu-70661" > Artificial human co...

  • Griffith, MayUniversity of Ottawa Eye Institute, Ottawa, Ontario, Canada (författare)

Artificial human corneas - Scaffolds for transplantation and host regeneration

  • Artikel/kapitelEngelska2002

Förlag, utgivningsår, omfång ...

  • Lippincott, Williams andamp; Wilkins,2002
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-70661
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70661URI
  • https://doi.org/10.1097/01.ico.0000263120.68768.f8DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Purpose. To review the development of artificial corneas (prostheses and tissue equivalents) for transplantation, and to provide recent updates on our tissue-engineered replacement corneas. Methods. Modified natural polymers and synthetic polymers were screened for their potential to replace damaged portions of the human cornea or the entire corneal thickness. These polymers, combined with cells derived from each of the three main corneal layers or stem cells, were used to develop artificial corneas. Functional testing was performed in vitro. Trials of biocompatibility and immune and inflammatory reactions were performed by implanting the most promising polymers into rabbit corneas. Results. Collagen-based biopolymers, combined with synthetic crosslinkers or copolymers, formed effective scaffolds for developing prototype artificial corneas that could be used as tissue replacements in the future. We have previously developed an artificial cornea that mimicked key morphologic and functional properties of the human cornea. The addition of synthetic polymers increased its toughness as it retained transparency and low light scattering, making the matrix scaffold more suitable for transplantation. These new composites were implanted into rabbits without causing any acute inflammation or immune response. We have also fabricated full-thickness composites that can be fully sutured. However, the long-term effects of these artificial corneas need to be evaluated. Conclusions. Novel tissue-engineered corneas that comprise composites of natural and synthetic biopolymers together with corneal cell lines or stem cells will, in the future, replace portions of the cornea that are damaged. Our results provide a basis for the development of both implantable temporary and permanent corneal replacements.

Ämnesord och genrebeteckningar

  • artificial corneas; keratoprostheses; polymers; tissue engineering; tissue equivalents; transplantation
  • TECHNOLOGY
  • TEKNIKVETENSKAP

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hakim, MalikUniversity of Ottawa Eye Institute, Ottawa, Ontario, Canada and National Research Council of Canada - ICPET, Ottawa, Ontario, Canada (författare)
  • Shimmura, ShigetoDental College, Ichikawa General Hospital Cornea Center, Ichikawa, Chiba, Japan (författare)
  • Watsky, Mitchell A.Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA (författare)
  • Li, FengfuUniversity of Ottawa Eye Institute, Ottawa, Ontario, Canada and National Research Council of Canada - ICPET, Ottawa, Ontario, Canada (författare)
  • Carlsson, DavidNational Research Council of Canada - ICPET, Ottawa, Ontario, Canada (författare)
  • Doillon, Charles J.Oncology and Molecular Endocrinology Research Center, Laval University, Quebec, Canada (författare)
  • Nakamura, MasatsuguSanten Pharmaceutical Co. Ltd., Nara R&D Center, Ikoma-shi, Nara, Japan (författare)
  • Suuronen, ErikUniversity of Ottawa Eye Institute, Ottawa, Ontario, Canada (författare)
  • Shinozaki, NaoshiDental College, Ichikawa General Hospital Cornea Center, Ichikawa, Chiba, Japan (författare)
  • Nakata, KatsuhikoSanten Pharmaceutical Co. Ltd., Nara R&D Center, Ikoma-shi, Nara, Japan (författare)
  • Sheardown, HeatherDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada (författare)
  • University of Ottawa Eye Institute, Ottawa, Ontario, CanadaUniversity of Ottawa Eye Institute, Ottawa, Ontario, Canada and National Research Council of Canada - ICPET, Ottawa, Ontario, Canada (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cornea: Lippincott, Williams andamp; Wilkins21:7, s. S54-S610277-37401536-4798

Internetlänk

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  • Cornea (Sök värdpublikationen i LIBRIS)

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