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Innervated human co...
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Suuronen, Erik J.University of Ottawa Eye Institute, Ottawa Health Research Institute-Vision Centre, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
(författare)
Innervated human corneal equivalents as in vitro models for nerve-target cell interactions
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
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2003-11-03
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Federation of American Society of Experimental Biology (FASEB),2003
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-70677
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70677URI
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https://doi.org/10.1096/fj.03-0043fjeDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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A sensory nerve supply is crucial for optimal tissue function. However, the mechanisms for successful innervation and the signaling pathways between nerves and their target tissue are not fully understood. Engineered tissue substitutes can provide controllable environments in which to study tissue innervation. We have therefore engineered human corneal substitutes that promote nerve in-growth in a pattern similar to in vivo re-innervation. We demonstrate that these nerves (a) are morphologically equivalent to natural corneal nerves; (b) make appropriate contact with target cells; (c) can generate action potentials; (d) respond to chemical and physical stimuli; and (e) play an important role in the overall functioning of the bioengineered tissue. This model can be used for studying the more general topics of nerve ingrowth or regeneration and the interaction between nerves and their target cells and, more specifically, the role of nerves in corneal function. This model could also be used as an in vitro alternative to animals for safety and efficacy testing of chemicals and drugs.
Ämnesord och genrebeteckningar
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extracellular matrix; innervation; cornea; nerve function; tissue engineering
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TECHNOLOGY
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TEKNIKVETENSKAP
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nakamura, MasatsuguSanten Pharmaceutical Company Ltd., Ikoma-shi, Nara, Japan
(författare)
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Watsky, Mitchell A.Department of Physiology, University of Tennessee Health Science Centre, Memphis, Tennessee, USA
(författare)
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Stys, Peter K.Ottawa Health Research Institute, Division of Neuroscience, University of Ottawa, Ottawa, Canada;
(författare)
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Muller, Linda J.Department of Morphology, The Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands
(författare)
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Munger, Rejean E.Tokyo Dental College-Ichikawa General Hospital Cornea Centre, Ichikawa, Chiba, Japan
(författare)
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Shinozaki, NaoshiTokyo Dental College-Ichikawa General Hospital Cornea Centre, Ichikawa, Chiba, Japan
(författare)
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Griffith, MayUniversity of Ottawa Eye Institute, Ottawa Health Research Institute-Vision Centre, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada(Swepub:liu)maygr76
(författare)
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University of Ottawa Eye Institute, Ottawa Health Research Institute-Vision Centre, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, CanadaSanten Pharmaceutical Company Ltd., Ikoma-shi, Nara, Japan
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The FASEB Journal: Federation of American Society of Experimental Biology (FASEB)17, s. 170-+0892-66381530-6860
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