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Molecular character...
Molecular characterization of the interaction between the disordered c-Myc transactivation domain and the TATA-binding protein (TBP)
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- Andrésen, Cecilia (författare)
- Linköpings universitet,Molekylär Bioteknik,Tekniska högskolan
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- Anandapadamanaban, Madhanagopal (författare)
- Linköpings universitet,Molekylär Bioteknik,Tekniska högskolan
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- Helander, Sara (författare)
- Linköpings universitet,Molekylär Bioteknik,Tekniska högskolan
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visa fler...
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- Fladvad, Malin (författare)
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S171 77 Stockholm
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- Andersson, Karl (författare)
- Biacore AB, GE Healthcare Europe GmbH, Björkgatan 30, SE-571 25 Uppsala, Sweden
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- Kanmert, Daniel (författare)
- Linköpings universitet,Molekylär Bioteknik,Tekniska högskolan
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- Säfsten, Pär (författare)
- Biacore AB, GE Healthcare Europe GmbH, Björkgatan 30, SE-571 25 Uppsala, Sweden
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- Moche, Martin (författare)
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S171 77 Stockholm
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- Sunnerhagen, Maria (författare)
- Linköpings universitet,Molekylär Bioteknik,Tekniska högskolan
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visa färre...
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The proto-oncogene c-myc affects the occurrence, expansion, and evolution of numerous aggressive human cancers, and is often associated with the late-stage and/or poor prognostic disease. Regulation of target gene activity by c-Myc occurs through protein interactions with the c-Myc transactivation domain (TAD) which, in addition to binding the TATA-binding protein (TBP) also recruits a wide variety of co-activators and suppressor proteins. Here, we present a molecular model, based on NMR, X-ray crystallography and SPR measurements, which describes how the c-Myc TAD binds to TBP. Our model contributes to the understanding of how c-Myc can regulate individual genes as well as entire gene programs.
Nyckelord
- NATURAL SCIENCES
- NATURVETENSKAP
Publikations- och innehållstyp
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