Sökning: onr:"swepub:oai:DiVA.org:liu-71507" >
Vitamin D status an...
-
Liu, Licette C YUniversity of Groningen
(författare)
Vitamin D status and outcomes in heart failure patients
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
-
2014-02-18
-
Wiley,2011
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-71507
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71507URI
-
https://doi.org/10.1093/eurjhf/hfr032DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
AIMS: Vitamin D status has been implicated in the pathophysiology of heart failure (HF). The aims of this study were to determine whether a low vitamin D status is associated with prognosis in HF and whether activation of the renin-angiotensin system (RAS) and inflammatory markers could explain this potential association. METHODS AND RESULTS: We measured 25-hydroxy-vitamin D (25(OH)D), plasma renin activity (PRA), interleukin-6 (IL-6), C-reactive protein (CRP), and the incidence of death or HF rehospitalization in 548 patients with HF. Median age was 74 (64-80) years, left ventricular ejection fraction was 30% (23-42), and mean follow-up was 18 months. Low 25(OH)D levels were associated with female gender (P< 0.001), higher age (P= 0.002), and higher N-terminal pro-brain natriuretic peptide (NT-proBNP) levels (P< 0.001). Multivariable linear regression analysis showed that PRA (P= 0.048), and CRP levels (P= 0.006) were independent predictors of 25(OH)D levels. During follow-up, 155 patients died and 142 patients were rehospitalized. Kaplan-Meier analysis showed that lower 25(OH)D concentration was associated with an increased risk for the combined endpoint (all-cause mortality and HF rehospitalization; log rank test P= 0.045) and increased risk for all-cause mortality (log rank test P= 0.014). After adjustment in a multivariable Cox regression analysis, low 25(OH)D concentration remained independently associated with an increased risk for the combined endpoint [hazard ratio (HR) 1.09 per 10 nmol/L decrease; 95% confidence interval (CI) 1.00-1.16; P= 0.040] and all-cause mortality (HR 1.10 per 10 nmol/L decrease; 95% CI 1.00-1.22; P= 0.049). CONCLUSION: A low 25(OH)D concentration is associated with a poor prognosis in HF patients. Activation of the RAS and inflammation may confer the adverse effects of low vitamin D levels.
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Voors, Adriaan AUniversity of Groningen
(författare)
-
van Veldhuisen, Dirk JUniversity of Groningen
(författare)
-
van der Veer, EvelineUniversity of Groningen
(författare)
-
Belonje, Anne MUniversity of Groningen
(författare)
-
Szymanski, Mariusz KUniversity of Groningen
(författare)
-
Silljé, Herman H WUniversity of Groningen
(författare)
-
van Gilst, Wiek HUniversity of Groningen
(författare)
-
Jaarsma, TinyLinköpings universitet,Hälsa, Aktivitet, Vård (HAV),Hälsouniversitetet(Swepub:liu)tinja77
(författare)
-
de Boer, Rudolf AUniversity of Groningen
(författare)
-
University of GroningenHälsa, Aktivitet, Vård (HAV)
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:European Journal of Heart Failure: Wiley13:6, s. 619-6251388-98421879-0844
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Liu, Licette C Y
-
Voors, Adriaan A
-
van Veldhuisen, ...
-
van der Veer, Ev ...
-
Belonje, Anne M
-
Szymanski, Mariu ...
-
visa fler...
-
Silljé, Herman H ...
-
van Gilst, Wiek ...
-
Jaarsma, Tiny
-
de Boer, Rudolf ...
-
visa färre...
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Linköpings universitet