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In vitro susceptibi...
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Östholm Balkhed, ÅseÖstergötlands Läns Landsting,Linköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet
(författare)
In vitro susceptibility of CTX-M-producing Escherichia coli to non-beta-lactam agents
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-76133
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76133URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:ovr swepub-publicationtype
Anmärkningar
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Background: The objective of this study was to investigate the in vitro activity of different antibiotics against CTX-M-producing Escherichia coli, to determine the occurrence of multiresistance and plasmid mediated quinolone resistance among these isolates. Methods: A total of 198 isolates of E. coli with ESBL phenotype and mainly CTX-M genotype, were studied. The MICs for amikacin, chloramphenicol, ciprofloxacin, colistin, fosfomycin, gentamicin, nalidixic acid, nitrofurantoin, tigecycline, tobramycin, trimethoprim and trimethoprim-sulphamethoxazole were determined with the Etest. Susceptibility was defined according to the breakpoints of the European Committee on Antimicrobial Susceptibility Testing (EUCAST). MIC(50) and MIC(90) values were calculated. Results: ≥95% of isolates were susceptible to amikacin, nitrofurantoin, colistin, tigecyclin, and fosfomycin. CTX-M group 9 was more susceptible than CTX-M group 1 to ciprofloxacin, gentamicin, and tobramycin. 68% of the isolates were multiresistant, and the most common multi-resistance pattern was ESBL-phenotype with decreased susceptibility to trimethoprim, trimethoprim-sulphamethoxazol, ciprofloxacin, gentamicin and tobramycin. Only one isolate carried a qnrS1-gene, nine isolates carried aac(6’)-Ib-cr. Conclusions: The high frequency of multi-resistance found in this study is alarming and it is urgent to find strategies to limit the emergence and spread of these multi-resistant strains.
Ämnesord och genrebeteckningar
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Etest
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MIC
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ESBL
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Tärnberg, MariaLinköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet(Swepub:liu)marta92
(författare)
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Monstein, Hans-JurgÖstergötlands Läns Landsting,Linköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet(Swepub:liu)hanmo19
(författare)
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Hällgren, AnitaÖstergötlands Läns Landsting,Linköpings universitet,Infektionsmedicin,Hälsouniversitetet,Infektionskliniken i Östergötland(Swepub:liu)aniha32
(författare)
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Hanberger, HåkanÖstergötlands Läns Landsting,Linköpings universitet,Infektionsmedicin,Hälsouniversitetet,Infektionskliniken i Östergötland(Swepub:liu)hakha84
(författare)
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Nilsson, Lennart ELinköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet(Swepub:liu)lenni43
(författare)
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Linköpings universitetKlinisk mikrobiologi
(creator_code:org_t)
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