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Combinatorial Activ...
Combinatorial Activation and Repression by Seven Transcription Factors Specify Drosophila Odorant Receptor Expression
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- Jafari, Shadi (författare)
- Linköpings universitet,Hälsouniversitetet,Cellbiologi,Linköpings universitet, Institutionen för klinisk och experimentell medicin
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- Alkhori, Liza (författare)
- Linköpings universitet,Hälsouniversitetet,Cellbiologi,Linköpings universitet, Institutionen för klinisk och experimentell medicin
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- Schleiffer, Alexander (författare)
- Research Institute Molecular Pathol IMP, Vienna
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- Brochtrup, Anna (författare)
- University of Vienna
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- Hummel, Thomas (författare)
- University of Vienna
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- Alenius, Mattias (författare)
- Linköpings universitet,Utvecklingsbiologi,Hälsouniversitetet,Linköpings universitet, Utvecklingsbiologi
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(creator_code:org_t)
- 2012-03-13
- 2012
- Engelska.
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Ingår i: PLoS biology. - : Public Library of Science. - 1544-9173 .- 1545-7885. ; 10:3, s. e1001280-
- Relaterad länk:
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https://journals.plo...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The mechanism that specifies olfactory sensory neurons to express only one odorant receptor (OR) from a large repertoire is critical for odor discrimination but poorly understood. Here, we describe the first comprehensive analysis of OR expression regulation in Drosophila. A systematic, RNAi-mediated knock down of most of the predicted transcription factors identified an essential function of acj6, E93, Fer1, onecut, sim, xbp1, and zf30c in the regulation of more than 30 ORs. These regulatory factors are differentially expressed in antennal sensory neuron classes and specifically required for the adult expression of ORs. A systematic analysis reveals not only that combinations of these seven factors are necessary for receptor gene expression but also a prominent role for transcriptional repression in preventing ectopic receptor expression. Such regulation is supported by bioinformatics and OR promoter analyses, which uncovered a common promoter structure with distal repressive and proximal activating regions. Thus, our data provide insight into how combinatorial activation and repression can allow a small number of transcription factors to specify a large repertoire of neuron classes in the olfactory system.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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