Sökning: onr:"swepub:oai:DiVA.org:liu-77527" >
A bisphosphonate-co...
-
Abtahi, JahanÖstergötlands Läns Landsting,Linköpings universitet,Ortopedi,Hälsouniversitetet,Käkkliniken US
(författare)
A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
-
Elsevier,2012
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-77527
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77527URI
-
https://doi.org/10.1016/j.bone.2012.02.001DOI
-
https://gup.ub.gu.se/publication/160765URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding Agencies|Swedish Research Council|VR 2009-6725|
-
Many surgical procedures use metal implants in bone. The clinical results depend on the strength of the bone holding these implants. Our objective was to show that a drug released from the implant surface can improve parameters reflecting the quality or amount of this bone. Sixteen patients received paired dental titanium implants in the maxilla, in a randomized, double-blinded fashion. One implant in each pair was coated with a thin fibrinogen layer containing 2 bisphosphonates. The other implant was untreated. Fixation was evaluated by measurement of resonance frequency (implant stability quotient; ISQ) serving as a proxy for stiffness of the implant-bone construct. Increase in ISQ at 6 months of follow-up was the primary variable. None of the patients had any complications. The resonance frequency increased 6.9 ISQ units more for the coated implants (p = 0.0001; Cohens d = 1.3). The average difference in increase in ISQ and the effect size, suggested a clinically relevant improvement. X-ray showed less bone resorption at the margin of the implant both at 2 months (p = 0.012) and at 6 months (p = 0.012). In conclusion, a thin, bisphosphonate-eluting fibrinogen coating might improve the fixation of metal implants in human bone. This might lead to new possibilities for orthopedic surgery in osteoporotic bone and for dental implants.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Tengvall, PenttiGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xtenpe
(författare)
-
Aspenberg, PerLinköpings universitet,Östergötlands Läns Landsting,Ortopedkliniken i Linköping,Ortopedi,Hälsouniversitetet(Swepub:liu)peras36
(författare)
-
Linköpings universitetOrtopedi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Bone: Elsevier50:5, s. 1148-11518756-32821873-2763
Internetlänk
Hitta via bibliotek
-
Bone
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas