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Sökning: onr:"swepub:oai:DiVA.org:liu-77753" > MyD88 in hematopoie...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003481nam a2200301 4500
001oai:DiVA.org:liu-77753
003SwePub
008120528| | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-777532 URI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a ovr2 swepub-publicationtype
1001 a Ruud, Johanu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)johru61
2451 0a MyD88 in hematopoietic cells, but not in cerebrovascular endothelial cells or neural cells, is critical for inflammation- and cancer-induced loss of appetite
338 a print2 rdacarrier
520 a Loss of appetite concomitant with reduced food intake is a hallmark of both acute and chronic inflammatory diseases. Yet, despite extensive investigations, the underlying mechanisms remain undefined. Here we addressed this issue using mice lacking MyD88, critical for Tolllike and IL-1 receptor family signaling, generally or in specific cell types. Ubiquitous null deletions conferred complete resistance to bacterial lipopolysaccharide (LPS) induced anorexia, but this resistance was lost when knock-out mice subjected to whole-body irradiation to delete hematopoietic cells were transplanted with wild-type bone-marrow. In line with this observation, mice lacking MyD88 in hematopoietic cells were largely protected against LPS-induced anorexia, whereas mice with abrogated MyD88 signaling in neural cells, being leaner and smaller, developed anorexia of similar magnitude as wild-type littermates. The effect of hematopoietic MyD88-deletion on feeding seemed however partially dissociated from the effect on body weight, since LPS triggered weight loss, although attenuated, in these mutants. Furthermore, MyD88 deficiency in the cerebrovascular endothelium affected neither LPS-induced anorexia nor weight loss. In a model for the cancer anorexia-cachexia syndrome, inactivation of MyD88 in hematopoietic cells strongly impaired the anorexia development and protected against body weight loss. These findings identify hematopoietic cells as a critical nexus for acute inflammatory driven anorexia as well as for chronic anorexia associated with malignant disease.
7001 a Björk Wilhelms, Danielu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)danbj96
7001 a Nilsson, Annau Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)annni62
7001 a Eskilsson, Annau Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)annes38
7001 a Yan-Juan, Tangu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)yanta19
7001 a Bäckhed, Fredriku Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut
7001 a Lundholm, Kentu Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden4 aut
7001 a Engblom, Davidu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)daven69
7001 a Blomqvist, Andersu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)andbl47
7102 a Linköpings universitetb Cellbiologi4 org
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77753

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