Sökning: onr:"swepub:oai:DiVA.org:liu-79573" >
In vitro Lymphocyte...
In vitro Lymphocyte Proliferation as Compared to Patch Test Using Gold, Palladium and Nickel
-
- Cederbrant, Karin (författare)
- Linköpings universitet,Kirurgi,Patologi,Hälsouniversitetet
-
- Hultman, Per (författare)
- Linköpings universitet,Patologi,Hälsouniversitetet
-
- Marcusson, Jan A. (författare)
- Department of Dermatology, Huddinge Hospital, Huddinge
-
visa fler...
-
- Tibbling, Lita (författare)
- Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet
-
visa färre...
-
(creator_code:org_t)
- 2009-09-04
- 1997
- Engelska.
-
Ingår i: International Archives of Allergy and Immunology. - : S. Karger AG. - 1018-2438 .- 1423-0097. ; 112:3, s. 212-217
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: A conventional lymphocyte transformation test (LTT) was compared to the commercially available MELISA® (memory lymphocyte immuno-stimulation assay), a lymphoproliferative assay that has been suggested to be a valuable instrument for the diagnosis of metal allergy. Sensitivity and specificity of the two assays were calculated using a patch test as a reference method.Methods: 34 patients were patch-tested for gold sodium thiosulfate, palladium chloride and nickel sulfate, and the lymphocyte proliferation to these metals was tested in vitro using mononuclear cells from peripheral blood.Results: No significant differences regarding sensitivity and specificity were found between MELISA and conventional LTT. The sensitivity varied between 55 and 95% and the specificity between 17 and 79%.Conclusions: The low specificity of the two in vitro assays suggests that they are not useful for diagnosis of contact allergy to the metals gold, palladium and nickel, since a large number of false-positive results will be obtained.
Nyckelord
- Lymphocytes human
- Skin test
- Metals
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas