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CD38 :
CD38 : a NAADP degrading enzyme
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- Schmid, Frederike (författare)
- University Medical Centre Hamburg-Eppendorf, Germany
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- Bruhn, Sören, 1976- (författare)
- University Medical Centre Hamburg-Eppendorf, Germany
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- Weber, Karin (författare)
- University Medical Centre Hamburg-Eppendorf, Germany
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- Mitrücker, Hans (författare)
- University Medical Centre Hamburg-Eppendorf, Germany
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- Guse, Andreas (författare)
- University Medical Centre Hamburg-Eppendorf, Germany
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(creator_code:org_t)
- 2011-10-19
- 2011
- Engelska.
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Ingår i: FEBS Letters. - : Elsevier. - 0014-5793 .- 1873-3468. ; 585:22, s. 3544-3548
- Relaterad länk:
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https://febs.onlinel...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The role of the multifunctional enzyme CD38 in formation of the Ca2+-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADPdegrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells.
Nyckelord
- Calcium signalling; NAADP; CD38; Jurkat T lymphocyte
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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