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Apoptosis and cancer :
Apoptosis and cancer : mutations within caspase genes
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- Ghavami, S. (författare)
- University of Manitoba, Winnipeg, Canada
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- Hashemi, M. (författare)
- Zahedan University of Medical Sciences, Iran
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- Ande, S. R. (författare)
- MICB, CancerCare Manitoba, Winnipeg, Canada
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- Yeganeh, B. (författare)
- St Boniface General Hospital Research Centre and University of Manitoba, Winnipeg, Canada
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- Xiao, W. (författare)
- MICB, CancerCare Manitoba, Winnipeg, Canada
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- Eshraghi, M. (författare)
- MICB, CancerCare Manitoba, Winnipeg, Canada
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- Bus, C. J. (författare)
- University of Tübingen, Germany
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- Kadkhoda, K. (författare)
- University of Manitoba and Diagnostic Services of Manitoba, Winnipeg, Canada
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- Wiechec, Emilia (författare)
- University of Aarhus, Denmark
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- Halayko, A. J. (författare)
- University of Manitoba, Winnipeg, Canada
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- Los, Marek (författare)
- University of Tübingen, Germany
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(creator_code:org_t)
- 2009-06-07
- 2009
- Engelska.
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Ingår i: Journal of Medical Genetics. - : B M J Group. - 0022-2593 .- 1468-6244. ; 46:8, s. 497-510
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://jmg.bmj.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead to tumorigenesis, autoimmunity, and other serious health problems. Deregulated apoptosis may also be the leading cause of cancer therapy chemoresistance. Caspase family of cysteinyl-proteases plays the key role in the initiation and execution of programmed cell death. This review gives an overview of the role of caspases, their natural modulators like IAPs, FLIPs, and Smac/Diablo in apoptosis and upon inactivation, and also in cancer development. Besides describing the basic mechanisms governing programmed cell death, a large part of this review is dedicated to previous studies that were focused on screening tumours for mutations within caspase genes as well as their regulators. The last part of this review discusses several emerging treatments that involve modulation of caspases and their regulators. Thus, we also highlight caspase cascade modulating experimental anticancer drugs like cFLIP-antagonist CDDO-Me; cIAP1 antagonists OSU-03012 and ME-BS; and XIAP small molecule antagonists 1396-11, 1396-12, 1396-28, triptolide, AEG35156, survivin/Hsp90 antagonist shephedrin, and some of the direct activators of procaspase-3.
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Ghavami, S.
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Hashemi, M.
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Ande, S. R.
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Yeganeh, B.
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Xiao, W.
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Eshraghi, M.
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visa fler...
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Bus, C. J.
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Kadkhoda, K.
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Wiechec, Emilia
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Halayko, A. J.
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Los, Marek
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