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Anticancer drugs of...
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Los, Marek JanInstitute of Experimental Dermatology, University of Muenster, Germany
(författare)
Anticancer drugs of tomorrow : apoptotic pathways as targets for drug design
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
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Elsevier,2003
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-87007
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-87007URI
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https://doi.org/10.1016/S1359-6446(02)02563-1DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Apoptosis or programmed cell death is a set of ordered events that enables the selective removal of cells from tissue and is essential for homeostasis and proper function of multicellular organisms. Components of this signaling network, which include ligands, such as CD95, tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand, as well as downstream molecules, such as caspases, Bcl-2 family members, and inhibitor-of-apoptosis proteins, which trigger and regulate apoptosis, are crucial targets for conventional drug development and gene therapy of cancer and other diseases. Here, we focus on apoptotic pathways and propose new potential molecular targets that could prove effective in controlling cell death in the clinical setting.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Burek, C. J.Institute of Experimental Dermatology, University of Muenster, Germany
(författare)
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Stroh, C.Institute of Experimental Dermatology, University of Muenster, Germany
(författare)
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Benedyk, K.Dept of Tumor Biology Oncology Center, Maria Sklodowska-Curie Memorial Institute, Wybrzeze Armii Krajowej 15, PL-44100 Gliwice, Poland
(författare)
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Hug, H.TheraSTrat AGGewerbestrasse 25, CH-4123, Allschwil, Switzerland
(författare)
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Mackiewicz, A.Dept of Cancer Immunology, University of Medical Sciences, at Great-Poland Cancer Center, Poznan, Poland
(författare)
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Institute of Experimental Dermatology, University of Muenster, GermanyDept of Tumor Biology Oncology Center, Maria Sklodowska-Curie Memorial Institute, Wybrzeze Armii Krajowej 15, PL-44100 Gliwice, Poland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Drug Discovery Today: Elsevier8:2, s. 67-771359-64461878-5832
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