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Inhibition of Activ...
Inhibition of Activation of Transcription Factor Ap-1 by Cd28 Signaling
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- Los, Marek Jan (författare)
- Division of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
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- Droge, W. (författare)
- Division of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
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- Schulze-Osthoff, Klaus (författare)
- Division of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
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Division of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany (creator_code:org_t)
- 1994
- 1994
- Engelska.
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Ingår i: Biochemical Journal. - 0264-6021 .- 1470-8728. ; 302, s. 119-123
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Abstract
Ämnesord
Stäng
- Co-stimulation of T-lymphocytes by T-cell receptor (TcR) occupancy and activation of the CD28 surface molecule results in enhanced proliferation and interleukin 2 (IL-2) production. The increase in IL-2 gene expression triggered by CD28 involves a KB-like sequence in the 5'-regulatory region of the IL-2 promoter, called CD28-responsive element. Stimulation of T-cells by agonistic anti-CD28 antibodies in conjunction with phorbol 12-myristate 13-acetate (PMA)- or TcR-derived signals induces the enhanced activation of the transcription factor NF-B-K. Here we report that CD28 engagement, however, exerts opposite effects on the transcription factor AP-1. Whereas anti-CD28 together with PMA increased the DNA binding and trans-activation activity of NF-B-K, PMA-induced activation of AP-1 was significantly suppressed. The inhibitory effect exerted by anti-CD38 was observed at the level of DNA binding as well as in functional reporter-gene assays. These results suggest that the two transcription factors are independently regulated and may perform different functions during T-cell activation.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- antigen
- c-fos
- death
- expression
- interleukin-2 gene
- lymphocytes
- nf-kappa-b
- pathway
- phosphorylation
- receptor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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