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Sökning: onr:"swepub:oai:DiVA.org:liu-90075" > Serum adipokines as...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003768naa a2200493 4500
001oai:DiVA.org:liu-90075
003SwePub
008130319s2013 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:126167908
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-900752 URI
0247 a https://doi.org/10.1002/dmrr.23782 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1261679082 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nguyet Pham, Minhu University of Dusseldorf, Germany4 aut
2451 0a Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin
264 c 2013-02-05
264 1b John Wiley and Sons,c 2013
338 a print2 rdacarrier
500 a Funding Agencies|European Association for the Study of Diabetes (EFSD)||German Diabetes Association (DDG)||Deutsches Zentrum fur Diabetesforschung (DZD) e.V.||
520 a Background We investigated the adipokines adiponectin, leptin and resistin as serum biomarkers of beta-cell function in patients with type 1 diabetes. Methods One hundred and eighteen patients with type 1 diabetes (20.3 +/- 7.5years) diagnosed andlt;5years underwent standardized mixed meal test (MMTT) for 2h. Systemic concentrations of C-peptide, adiponectin, leptin and resistin obtained during MMTT were measured and compared between patient groups by multiple regression analysis. Results Patients were divided by their adipokine levels in subgroups above or below the median level (high versus low). High adiponectin levels (andgt;10.6 mu g/mL) were associated with lower C-peptide compared to the low adiponectin subgroup (pandlt;0.03). Increased leptin or resistin concentrations associated positively with beta-cell function even after adjustment for metabolic confounders (pandlt;0.04). The described associations between adipokines and C-peptide concentrations persisted in Spearman correlation tests (pandlt;0.05). Serum adipokines fell during MMTT (pandlt;0.05). Conclusions Serum adipokine levels differentially correlate with beta-cell function in type 1 diabetes independent of BMI or metabolic control. Serum adipokines should be investigated as biomarkers of beta-cell function in prospective studies and intervention trials in type 1 diabetes.
653 a adipokine
653 a adiponectin
653 a C-peptide
653 a leptin
653 a resistin
653 a type 1 diabetes
653 a MEDICINE
653 a MEDICIN
7001 a Kolb, Hubertu University of Dusseldorf, Germany4 aut
7001 a Mandrup-Poulsen, Thomasu University of Copenhagen, Denmark4 aut
7001 a Battelino, Tadeju University of Childrens Hospital, Slovenia4 aut
7001 a Ludvigsson, Johnnyu Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping4 aut0 (Swepub:liu)johlu29
7001 a Pozzilli, Paolou University of Campus BioMed, Italy4 aut
7001 a Roden, Michaelu University of Dusseldorf, Germany4 aut
7001 a Schloot, Nanette C.u University of Dusseldorf, Germany4 aut
7102 a University of Dusseldorf, Germanyb University of Copenhagen, Denmark4 org
7730 t Diabetes/Metabolism Research Reviewsd : John Wiley and Sonsg 29:2, s. 166-170q 29:2<166-170x 1520-7552x 1520-7560
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90075
8564 8u https://doi.org/10.1002/dmrr.2378
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:126167908

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