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Sökning: onr:"swepub:oai:DiVA.org:liu-90208" > Downregulation of m...

  • Wang, Mo-JinSichuan University, China (författare)

Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • 2012-08-11
  • Springer Verlag (Germany),2013
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-90208
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90208URI
  • https://doi.org/10.1007/s00384-012-1550-3DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|National Natural Science Foundation of China|30830100|Ph.D. Programs Foundation of the Ministry of Education of China|200806100058|
  • PurposeRecently, microRNA-124 (miR-124) has been demonstrated as a potential tumor suppressor in several types of cancers. However, the role of miR-124 in colorectal cancer remains unclear. This study was aimed at investigating the clinicopathological significance of miR-124 expression in colorectal cancer.MethodsQuantitative real-time PCR was used to analyze miR-124 expression in 96 colorectal cancers and individual-matched normal mucosa samples. The expression of miR-124 was assessed for associations with clinicopathological characteristics using chi-square test. The survival curves were calculated by the Kaplan–Meier method. The influence of each variable on survival was examined by the Cox multivariate regression analysis.ResultsThe miR-124 expression was significantly downregulated in colorectal cancer compared to normal mucosa (P = 0.001). In colorectal cancer, miR-124 decreased expression correlated significantly with the grade of differentiation (P  = 0.021). Univariate survival analysis showed that the downregulated miR-124 was significantly correlated with worse prognosis, both in terms of overall survival (P = 0.017) and disease-free survival (DFS) (P  = 0.014). Further, the downregulated miR-124 was demonstrated as a prognostic factor for overall survival (hazard ratio, HR = 4.634; 95 % confidence interval, CI, 1.731–12.404; P = 0.002) and DFS (HR = 4.533, 95 % CI 1.733–11.856, P = 0.002), independently of gender, age, location, maximum tumor size, depth of invasion, differentiation, and TNM stage.ConclusionsMiR-124 may play a certain role in the development of colorectal cancer. The downregulation expression of miR-124 is an independent prognostic factor in patients with colorectal cancer.

Ämnesord och genrebeteckningar

  • MicroRNA-124
  • Colorectal cancer
  • Quantitative real-time PCR
  • Survival
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Li, YuanSichuan University, China (författare)
  • Wang, RuiSichuan University, China (författare)
  • Wang, CunSichuan University, China (författare)
  • Yu, Yong-YangSichuan University, China (författare)
  • Yang, LieSichuan University, China (författare)
  • Zhang, YiSichuan University, China (författare)
  • Zhou, BinSichuan University, China (författare)
  • Zhou, Zong-GuangSichuan University, China (författare)
  • Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45 (författare)
  • Sichuan University, ChinaOnkologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Colorectal Disease: Springer Verlag (Germany)28:2, s. 183-1890179-19581432-1262

Internetlänk

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