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Akt2 expression is ...
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Fohlin, HelenaÖstergötlands Läns Landsting,Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet,Regionalt cancercentrum
(författare)
Akt2 expression is associated with good long-term prognosis in oestrogen receptor positive breast cancer
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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Elsevier,2013
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-92610
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-92610URI
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https://doi.org/10.1016/j.ejca.2012.12.006DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:126508742URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Swedish Cancer Society||Swedish Research Council||
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IntroductionAkt is a signalling modulator for many cellular processes, including metabolism, cell proliferation, cell survival and cell growth. Three isoforms of Akt have been identified, but only a few studies have concerned the isoform-specific roles in the prognosis of breast cancer patients. The aim of this study was to investigate the prognostic value of v-akt murine thymoma viral oncogene homologue 1 (Akt1) and v-akt murine thymoma viral oncogene homologue 2 (Akt2) in oestrogen receptor positive (ER+) and oestrogen receptor negative (ER–) breast cancer with long-term follow-up.Material and methodsThe expression of Akt in tumour tissue was analysed with immunohistochemistry in a cohort of 272 postmenopausal patients with stage II breast cancer. The median follow-up time was 19 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using the Cox’s proportional hazards model.ResultsThe risk of distant recurrence was reduced for patients with ER+ tumours expressing Akt2 compared to patients with no Akt2 expression (HR = 0.49, 95% CI 0.29–0.82, p = 0.007). When adjusting for important clinical tumour characteristics and treatment, Akt2 was still an independent prognostic factor (HR = 0.38, 95% CI 0.21–0.68, p = 0.001) and the association remained long-term. The prognostic value of Akt2 increased with higher oestrogen receptor levels from no effect among patients with ER– tumours to 68% risk reduction for the group with high ER-levels (P for trend = 0.042). Akt1 showed no significant prognostic information.ConclusionOur results indicate that Akt2 expression is associated with a lower distant recurrence rate for patients with ER+ tumours and that this association remains long-term. The prognostic value of Akt2 increases with higher oestrogen receptor expression, motivating further mechanistic studies on the role of Akt2 in ER+ breast cancer.
Ämnesord och genrebeteckningar
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Breast cancer
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Akt
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Protein kinase B
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Oestrogen receptor
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Long-term
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Prognostic factor
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MEDICINE
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MEDICIN
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Carstensen, JohnLinköpings universitet,Hälsa och samhälle,Hälsouniversitetet(Swepub:liu)johca98
(författare)
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Stål, OlleÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)ollst87
(författare)
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Linköpings universitetInstitutionen för klinisk och experimentell medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Cancer: Elsevier49:6, s. 1196-12040959-80491879-0852
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