Sökning: onr:"swepub:oai:DiVA.org:liu-93965" >
Time to secondary p...
Time to secondary progression in patients with multiple sclerosis who were treated with first generation immunomodulating drugs
-
- Tedeholm, Helen, 1978 (författare)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
-
- Lycke, Jan, 1956 (författare)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
-
- Skoog, Bengt (författare)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
-
visa fler...
-
- Lisovskaja, Vera, 1984 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers, Sweden
-
- Hillert, J (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden
-
- Dahle, Charlotte (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin,Linköping University
-
- Fagius, Jan (författare)
- Uppsala universitet,Neurologi,Karolinska University Hospital, Sweden
-
- Fredrikson, S (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden
-
- Landtblom, Anne-Marie (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken,Linköping University
-
- Malmeström, Clas, 1965 (författare)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
-
- Martin, C (författare)
- Karolinska Institutet,University Hospital, Sweden
-
- Piehl, F (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden
-
- Runmarker, B (författare)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
-
- Stawiarz, L (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden
-
- Vrethem, Magnus (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken,Linköping University
-
- Nerman, Olle, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers, Sweden
-
- Andersen, Oluf, 1941 (författare)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
-
visa färre...
-
(creator_code:org_t)
- 2012-11-01
- 2013
- Engelska.
-
Ingår i: Multiple Sclerosis Journal. - : SAGE Publications (UK and US). - 1352-4585 .- 1477-0970. ; 19:6, s. 765-774
- Relaterad länk:
-
https://liu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://europepmc.or...
-
http://publications.... (primary) (free)
-
https://uu.diva-port... (primary) (Raw object)
-
https://gup.ub.gu.se... (primary) (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://research.cha...
-
http://kipublication...
-
https://urn.kb.se/re...
-
https://gup.ub.gu.se...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: It is currently unknown whether early immunomodulatory treatment in relapsing-remitting MS (RRMS) can delay the transition to secondary progression (SP). less thanbrgreater than less thanbrgreater thanObjective: To compare the time interval from onset to SP in patients with RRMS between a contemporary cohort, treated with first generation disease modifying drugs (DMDs), and a historical control cohort. less thanbrgreater than less thanbrgreater thanMethods: We included a cohort of contemporary RRMS patients treated with DMDs, obtained from the Swedish National MS Registry (disease onset between 1995-2004, n = 730) and a historical population-based incidence cohort (onset 1950-64, n = 186). We retrospectively analyzed the difference in time to SP, termed the "period effect" within a 12-year survival analysis, using Kaplan-Meier and Cox regression analysis. less thanbrgreater than less thanbrgreater thanResults: We found that the "period" affected the entire severity spectrum. After adjusting for onset features, which were weaker in the contemporary material, as well as the therapy initiation time, the DMD-treated patients still exhibited a longer time to SP than the controls (hazard ratios: men, 0.32; women, 0.53). less thanbrgreater than less thanbrgreater thanConclusion: Our results showed there was a longer time to SP in the contemporary subjects given DMD. Our analyses suggested that this effect was not solely driven by the inclusion of benign cases, and it was at least partly due to the long-term immunomodulating therapy given.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Disease-modifying drugs
- disease progression
- disease severity
- epidemiology
- multiple sclerosis
- relapsing-remitting multiple sclerosis
- secondary progressive multiple sclerosis
- Sweden
- time to progression
- MEDICINE
- MEDICIN
- Neurology
- multipel skleros
- DMD
- progression
- RRMS
- SPMS
- bromsmedicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tedeholm, Helen, ...
-
Lycke, Jan, 1956
-
Skoog, Bengt
-
Lisovskaja, Vera ...
-
Hillert, J
-
Dahle, Charlotte
-
visa fler...
-
Fagius, Jan
-
Fredrikson, S
-
Landtblom, Anne- ...
-
Malmeström, Clas ...
-
Martin, C
-
Piehl, F
-
Runmarker, B
-
Stawiarz, L
-
Vrethem, Magnus
-
Nerman, Olle, 19 ...
-
Andersen, Oluf, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
Multiple Scleros ...
- Av lärosätet
-
Linköpings universitet
-
Chalmers tekniska högskola
-
Karolinska Institutet
-
Uppsala universitet
-
Göteborgs universitet