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Infliximab as rescu...
Infliximab as rescue therapy in hospitalised patients with steroid-refractory acute ulcerative colitis: a long-term follow-up of 211 Swedish patients
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- Sjöberg, Mats (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Skaraborgs Hospital, Lidköping, Sweden
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- Magnuson, A (författare)
- Clinical Epidemiology and Biostatistics Unit, Örebro University Hospital, Örebro, Sweden
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- Bjork, J (författare)
- Department of Gastroenterology and Hepatology, Karolinska University Hospital, Stockholm, Sweden
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- Benoni, Cecilia (författare)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden
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- Almer, Sven (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Magtarmmedicinska kliniken,Division of Gastroenterology and Hepatology, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Friis-Liby, I (författare)
- Division of Gastroenterology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Hertervig, Erik (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Gastroenterology, Skåne University Hospital, Lund, Sweden
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- Olsson, M (författare)
- Department of Medicine, NÄL Hospital, Trollhättan, Sweden
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- Karlen, P (författare)
- Karolinska Institutet,Soder Sjukhuset, Sweden,Division of Gastroenterology, Department of Medicine, South Hospital, Stockholm, Sweden
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- Eriksson, A (författare)
- Ostra Hospital, Sweden,Division of Gastroenterology, Department of Internal Medicine and Geriatrics, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Midhagen, Gunnar (författare)
- Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Skaraborgs Hospital, Lidköping, Sweden
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- Carlson, Marie (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Lapidus, A (författare)
- Department of Gastroenterology, Ersta Hospital, Stockholm, Sweden
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- Halfvarson, Jonas (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Tysk, Curt (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2013-06-25
- 2013
- Engelska.
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Wiley-Blackwell. - 0269-2813 .- 1365-2036. ; 38:4, s. 377-387
- Relaterad länk:
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BackgroundRescue therapy with infliximab (IFX) has been proven effective in a steroid-refractory attack of ulcerative colitis (UC). The long-term efficacy is not well described. less thanbrgreater than less thanbrgreater thanAimTo present a retrospective study of IFX as rescue therapy in UC. Primary end points were colectomy-free survival at 3 and 12months. less thanbrgreater than less thanbrgreater thanMethodsIn this multicentre study, 211 adult patients hospitalised between 1999 and 2010 received IFX 5mg/kg as rescue therapy due to a steroid-refractory, moderate-to-severe attack of UC. Exclusion criteria were duration of current flare for andgt;12weeks, corticosteroid treatment for andgt;8weeks before hospitalisation, previous IFX therapy or Crohns disease. less thanbrgreater than less thanbrgreater thanResultsProbability of colectomy-free survival at 3months was 0.71 (95% CI, 0.64-0.77), at 12months 0.64 (95% CI, 0.57-0.70), at 3years 0.59 (95% CI, 0.52-0.66) and at 5years 0.53 (95% CI, 0.44-0.61). Steroid-free, clinical remission was achieved in 105/211 (50%) and 112/209 (54%) patients at 3 and 12months respectively. Of 75 colectomies during the first year, 48 (64%) were carried out during the first 14days, 13 (17%) on days 15-90 and 14 (19%) between 3 and 12months. There were three (1.4%) deaths during the first 3months. less thanbrgreater than less thanbrgreater thanConclusionsInfliximab is an effective rescue treatment, both short- and long-term, in a steroid-refractory attack of UC. Most IFX failures underwent surgery during the first 14days, which calls for studies on how to optimise induction treatment with IFX. Serious complications, including mortality, were rare.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
- Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Sjöberg, Mats
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Magnuson, A
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Bjork, J
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Benoni, Cecilia
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Almer, Sven
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Friis-Liby, I
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Hertervig, Erik
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Olsson, M
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Karlen, P
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Eriksson, A
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Midhagen, Gunnar
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Carlson, Marie
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Lapidus, A
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Halfvarson, Jona ...
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Tysk, Curt
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Alimentary Pharm ...
- Av lärosätet
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Linköpings universitet
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Lunds universitet
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Karolinska Institutet
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Örebro universitet
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Uppsala universitet