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Overexpression of F...
Overexpression of FXYD-3 is involved in the tumorigenesis and development of esophageal squamous cell carcinoma
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- Zhu, Zhen-Long (författare)
- Hebei Medical University, Shijiazhuang, China
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- Yan, Bao-Yong (författare)
- Hebei Medical University, Shijiazhuang, China
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- Zhang, Yu (författare)
- Hebei Medical University, Shijiazhuang, China
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- Yang, Yan-Hong (författare)
- Hebei Medical University, Shijiazhuang, China
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- Wang, Ming-Wei (författare)
- Hebei Medical University, Shijiazhuang, China
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- Zentgraf, Hanswalter (författare)
- Heidelberg University, Germany
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- Zhang, Xiang-Hong (författare)
- Hebei Medical University, Shijiazhuang, China
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- Sun, Xiao-Feng (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US
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(creator_code:org_t)
- IOS Press, 2013
- 2013
- Engelska.
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Ingår i: Disease Markers. - : IOS Press. - 0278-0240 .- 1875-8630. ; 35:3, s. 195-202
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: To investigate the association of FXYD-3 expression with clinicopathological variables and PINCH in patients with ESCC.Patients and methods: Expression of FXYD-3 protein was immunohistochemically examined in normal esophageal mucous (n = 20) and ESCC (n = 64). Results: Expression of FXYD-3 in the cytoplasm markedly increased from normal esophageal epithelial cells to primary ESCC ( p = 0.001). The expression of FXYD-3 was correlated with TNM stages and depth of tumour invasion. Furthermore, the cases with lymph node metastasis tended to show a higher frequency of positive expression than those without metastasis ( p = 0.086), and FXYD-3 expression tended to be positively related to the expression of PINCH (p = 0.063). Moreover, the cases positive for both proteins had the highest frequency of lymph node metastasis (p = 0.001). However, FXYD-3 expression was not correlated with patient,s gender (p = 0.847), age (p = 0.876), tumour location (p = 0.279), size (p = 0.771) , grade of differentiation (p = 0.279), and survival (p = 0.113).Conclusion: overexpression of FXYD-3 in the cytoplasm may play an important role in the tumourigenesis and development in the human ESCC, particularly in combination with PINCH expression.
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