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AP-1 DNA-binding ac...
AP-1 DNA-binding activity is inhibited by selenite and selenodiglutathione
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- Spyrou, Giannis (författare)
- Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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- Björnstedt, M. (författare)
- Karolinska Institutet
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- Kumar, S. (författare)
- Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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- Holmgren, A. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 1995
- 1995
- Engelska.
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Ingår i: FEBS Letters. - : Elsevier. - 0014-5793 .- 1873-3468. ; 368:1, s. 59-63
- Relaterad länk:
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http://www.sciencedi...
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The binding of the transcription factor AP-1 to DNA has been shown to be modulated by redox control mechanisms. Selenite and selenodiglutathione (GS-Se-SG), inhibit mammalian cell growth and are efficient oxidants of reduced thioredoxin and reduced thioredoxin reductase. Here, we report that selenite and GS-Se-SG efficiently inhibited AP-1 DNA-binding in nuclear extracts from 3B6 lymphocytes. A GS-Se-SG concentration of 0.75 microM resulted in 50% inhibition of AP-1 DNA-binding, whereas the same effect was achieved with 7.5 microM selenite. Nuclear extracts prepared from human 3B6 lymphocytes exposed for 4 h to 10 microM selenite showed a 50% reduction of AP-1 binding. These data suggest that selenite and selenodiglutathione inactivate the AP-1 factor and provide a mechanism by which selenium compounds inhibit cell growth.
Nyckelord
- Selenium; Selenodiglutathione; Redox regulation; AP-1
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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