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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003625naa a2200385 4500
001oai:DiVA.org:liu-99314
003SwePub
008131015s2009 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-98482
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-993142 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-984822 URI
0247 a https://doi.org/10.1007/978-0-387-85998-9_312 DOI
040 a (SwePub)liud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Edlund, Jennyu Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)jeedl402
2451 0a Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging
264 1a Boston, MA :b Springer US,c 2009
338 a print2 rdacarrier
520 a By applying invasive techniques for direct measurements of oxygen tension, we have reported decreased kidney oxygenation in experimental diabetes in rats. However, the non-invasive MRI technique utilizing the BOLD effect provides several advantages with the possibility to perform repetitive measurements in the same animals and in human subjects. In this study, we applied a modified single gradient echo micro-imaging sequence to detect the BOLD effect in kidneys of diabetic rats and compared the results to normoglycemic controls. All measurements were performed on inactin-anaesthetized adult male Wistar Furth rats. Diabetes was induced by streptozotocin (45 mg/kg) 14 days prior to MRI-analysis. Sixteen T2*-weighted image records (B0=1.5 T) were performed using radiofrequency spoiled gradient echo sequence with 2.6 ms step increments of TE (TE1=12 ms), while TR (75 ms) and bandwidth per pixel (71.4 Hz) were kept constant. T2* maps were computed by mono-exponential fitting of the pixel intensities. Relaxation rates R2* (1/T2*) in cortex and outer stripe of the outer medulla were similar in both groups (cortex for controls 22.3 +/- 0.4 vs. diabetics 23.1 +/- 1.8 Hz and outer stripe of outer medulla for controls 24.9 +/- 0.4 vs. diabetics 26.4 +/- 1.8 Hz; n=4 in both groups), whereas R2* was increased in the inner stripe of the outer medulla in diabetic rats (diabetics 26.1 +/- 2.4 vs. controls 18.8 +/- 1.4 Hz; n=4, P<0.05). This study demonstrates that experimental diabetes in rats induces decreased oxygenation of the renal outer medulla. Furthermore, the proposed T2*-weighted MR micro-imaging technique is suitable for detection of regional changes in kidney oxygenation in experimental animal models.
653 a MEDICINE
653 a MEDICIN
7001 a Hansell, Peteru Uppsala universitet,Integrativ Fysiologi4 aut0 (Swepub:uu)petehans
7001 a Fasching, Angelicau Uppsala universitet,Integrativ Fysiologi4 aut0 (Swepub:uu)afa22979
7001 a Liss, Peru Uppsala universitet,Enheten för radiologi4 aut0 (Swepub:uu)perliss
7001 a Weis, Janu Uppsala universitet,Enheten för radiologi4 aut0 (Swepub:uu)janweis
7001 a Glickson, Jerry D.4 aut
7001 a Palm, Fredriku Uppsala universitet,Integrativ Fysiologi4 aut0 (Swepub:uu)fredpalm
7102 a Uppsala universitetb Institutionen för medicinsk cellbiologi4 org
7730 t Advances in Experimental Medicine and Biologyd Boston, MA : Springer USg 645, s. 199-204q 645<199-204x 0065-2598x 2214-8019
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-99314
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98482
8564 8u https://doi.org/10.1007/978-0-387-85998-9_31

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