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- Kinhult, JohanLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Malmö University Hospital, Sweden (författare)
Increased expression of surface activation markers on neutrophils following migration into the nasal lumen
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
- 2003-08-05
- Wiley-Blackwell,2003
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-99900
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-99900URI
- https://doi.org/10.1046/j.1365-2222.2003.01682.xDOI
- https://lup.lub.lu.se/record/117401URI
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- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- BACKGROUND: The sequence of events following the recruitment of a free-flowing neutrophil in the peripheral circulation, via adhesion, migration and release of mediators, to a neutrophil on the surface of the nasal epithelium is a co-ordinated process. Little is known about the state of neutrophil activation following this course of events.OBJECTIVES: To investigate the expression of surface activation markers on neutrophils, reflecting activation during their recruitment to the nose, and to see whether the inflammatory process during allergic rhinitis influences this process.METHOD: Nine healthy controls and 12 patients with grass pollen-induced intermittent allergic rhinitis were investigated during the peak of the pollen season. The expression of CD11b, CD66b and CD63 on the neutrophil cell surface, as a reflection of activation, was analysed using flow cytometry. Neutrophils were derived from peripheral blood and nasal lavage fluid. In addition, eosinophil cationic protein (ECP) and myeloperoxidase (MPO) as well as L-, P- and E-selectins in the nasal lavage fluid were analysed using RIA and ELISA, respectively.RESULTS: A marked increase in the expression of all three CD markers on the neutrophil cell surface was noticed following migration from the bloodstream to the surface of the nasal mucosa. At the peak of the grass pollen season, the MPO levels increased, reflecting an increase in the total number of nasal fluid neutrophils. In parallel, the expression of CD11b was further augmented. The expression of the CDb11b was reduced on neutrophils remaining in the circulation. In addition, the level of L-selectin was reduced on neutrophils derived from the blood during allergic inflammation.CONCLUSION: Neutrophils might become activated during their transfer from the blood to the surface of the nasal mucosa, but these changes may also be due to depletion of activated neutrophils in the blood via activated endothelial/epithelial adhesion and chemoattractant measures. The increased expression of surface activation markers during allergic rhinitis suggests roles for neutrophils in the inflammatory process.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
- allergic rhinitis
- CD11b
- CD63
- CD66b
- flow cytometry
- nasal lavage
- neutrophils
- selectins
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Egesten, ArneLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Malmö University Hospital, Sweden(Swepub:lu)mikr-aeg (författare)
- Benson, MikaelMalmö University Hospital, Sweden(Swepub:liu)mikbe05 (författare)
- Uddman, RolfLund University,Lunds universitet,Klinisk och experimentell allergiforskning,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Clinical and Experimental Allergy Research,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups,Malmö University Hospital, Sweden(Swepub:lu)oron-rud (författare)
- Cardell, Lars-OlafLund University,Lunds universitet,Klinisk och experimentell allergiforskning,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Clinical and Experimental Allergy Research,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups,Malmö University Hospital, Sweden(Swepub:lu)oron-lca (författare)
- Institutionen för kliniska vetenskaper, MalmöMedicinska fakulteten (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Clinical and Experimental Allergy: Wiley-Blackwell33:8, s. 1141-11460954-78941365-2222
Internetlänk
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12911790&dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1046/j.1365-2222.2003.01682.xFULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-99900
- https://doi.org/10.1046/j.1365-2222.2003.01682.x
- https://lup.lub.lu.se/record/117401
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- Clinical and Experimental Allergy (Sök värdpublikationen i LIBRIS)
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