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Inhibition of in-st...
Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries
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- Mandinov, L. (författare)
- Maine Medical Center, Scarborough, Maine, USA
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- L. Moodie, K. (författare)
- Dartmouth-Hitchcock Medical Center, Hanover, NH, USA
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- Mandinova, A. (författare)
- Maine Medical Center, Scarborough, Maine, USA
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- Zhuang, Z. (författare)
- Dartmouth-Hitchcock Medical Center, Hanover, NH, USA
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- Redican, F. (författare)
- Dartmouth-Hitchcock Medical Center, Hanover, NH, USA
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- Baklanov, D. (författare)
- Dartmouth-Hitchcock Medical Center, Hanover, NH, USA
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- Lindner, V. (författare)
- Maine Medical Center, Scarborough, Maine, USA
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- Maciag, T. (författare)
- Maine Medical Center, Scarborough, Maine, USA
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- Simons, M. (författare)
- Dartmouth-Hitchcock Medical Center, Hanover, NH, USA
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- de Muinck, Ebo D. (författare)
- Maine Medical Center, Scarborough, Maine, USA
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(creator_code:org_t)
- American Physiological Society, 2006
- 2006
- Engelska.
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Ingår i: American Journal of Physiology. Heart and Circulatory Physiology. - : American Physiological Society. - 0363-6135 .- 1522-1539. ; 291:6, s. H2692-H2697
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Stress-induced release of IL-1 alpha and fibroblast growth factor-1 is dependent on intracellular copper and is a major driver of neointimal hyperplasia. Therefore, we assessed the effect of tetrathiomolybdate (TTM), a clinically proven copper chelator, on in-stent restenosis. Nine pigs were treated with TTM (5 mg/kg po) twice daily for 2 wk before stent implantation and for 4 wk thereafter, and nine pigs served as controls. In-stent restenosis was assessed by quantitative coronary angiography (QCA), intravascular ultrasound (IVUS), and histomorphometry. Serum ceruloplasmin activity was used as a surrogate marker of copper bioavailability. In TTM-treated animals, ceruloplasmin dropped 70 +/- 10% below baseline levels. Baseline characteristics were comparable in TTM-treated and control animals. At 4-wk follow-up, all parameters relevant to in-stent restenosis were significantly reduced in TTM-treated animals: minimal lumen diameter by QCA was 2.03 +/- 0.57 and 1.47 +/- 0.45 mm in TTM-treated and control animals, respectively (P less than 0.05), percent stenosis diameter was 39% less in TTM-treated animals (27.1 +/- 16.6% vs. 44.5 +/- 16.1%, P less than 0.05), minimal lumen area by IVUS was 60% larger in TTM-treated animals (4.27 +/- 1.56 vs. 2.67 +/- 1.19 mm(2), P less than 0.05), and neointimal volume by histomorphometry was 37% less in TTM-treated animals (34.9 +/- 11.5 vs. 55.2 +/- 19.6 mm(3), P less than 0.05). We conclude that systemic copper chelation with a clinically approved chelator significantly inhibits in-stent restenosis.
Nyckelord
- inflammation; stent
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- ref (ämneskategori)
- art (ämneskategori)
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Mandinov, L.
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L. Moodie, K.
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Mandinova, A.
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Zhuang, Z.
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Redican, F.
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Baklanov, D.
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Lindner, V.
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Maciag, T.
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Simons, M.
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de Muinck, Ebo D ...
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