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Comparison of trans...
Comparison of transendocardial and retrograde coronary venous intramyocardial catheter delivery systems in healthy and infarcted pigs
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- Baklanov, D. V. (författare)
- Dartmouth Medical School, Hanover, NH, USA
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- Moodie, K. M. (författare)
- Dartmouth Medical School, Hanover, NH, USA
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- McCarthy, F. E. (författare)
- Dartmouth Medical School, Hanover, NH, USA
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- Mandrusov, E. (författare)
- Guidant Corp., Santa Clara, CA, USA
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- Chiu, J. (författare)
- Guidant Corp., Santa Clara, CA, USA
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- Aswonge, G. (författare)
- Guidant Corp., Santa Clara, CA, USA
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- Cheng, J. (författare)
- Guidant Corp., Santa Clara, CA, USA
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- Chow, M. (författare)
- Guidant Corp., Santa Clara, CA, USA
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- Simons, M. (författare)
- Dartmouth Medical School, Hanover, NH, USA
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- de Muinck, Ebo D. (författare)
- Dartmouth Medical School, Hanover, NH, USA
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Dartmouth Medical School, Hanover, NH, USA Guidant Corp, Santa Clara, CA, USA (creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: Catheterization and cardiovascular interventions. - : Wiley-Blackwell. - 1522-1946 .- 1522-726X. ; 68:3, s. 416-423
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- We compared two routes for myocardial delivery of therapeutics, transendocardial (TE) delivery with an intramyocardial injection catheter, and retrograde coronary venous (RCV) delivery with a balloon occlusion catheter in the interventricular vein. Methods: TE and RCV injection of 15 mu m, neutron-activatable microspheres was compared in healthy pigs (Group I, n = 3), pigs with a 1-week-old myocardial infarction (MI; group II, n = 5), and pigs with a 2-weeks-old MI (group III, n = 4). The MI was induced by a 1-hr balloon occlusion in the LAD. Both methods were compared in the same animal using different microspheres. The RCV catheter allowed for continuous measurement of distal pressure and 2.5 x 10(6) microspheres were injected in 10 ml at 300 mmHg above balloon occlusion pressure. The TE injections were targeted to the infarct zone and 2.5 x 10(6) microspheres were distributed over 10 injections of 200 mu l. Results: The retention of microspheres decreased with increase in MI age, but was comparable between devices within the groups. RCV delivery resulted in (14.3 +/- 0.9)% microsphere retention in Group I, (10.3 +/- 0.2)% in Group II, and (6.4 +/- 0.1)% in group III (P less than 0.05 versus group I). Microsphere retention after TE was (15.1 +/- 0.7)% in group I, (18.9 +/- 0.6)% in group II, (4.1 +/- 0.1)% in Group III (P less than 0.05 versus groups I and II). The RCV catheter delivered primarily to midventricular, antero-septal segments, whereas TE targeted apical areas predominantly. Conclusions: Delivery efficacy was comparable between devices in each group however RCV targeted midventricular areas whereas TE targeted apical areas.
Nyckelord
- myocardial infarction; percutaneous cardiac intervention; microspheres; myocardial uptake
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- ref (ämneskategori)
- art (ämneskategori)
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Baklanov, D. V.
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Moodie, K. M.
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McCarthy, F. E.
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Mandrusov, E.
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Chiu, J.
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Aswonge, G.
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visa fler...
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Cheng, J.
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Chow, M.
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Simons, M.
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de Muinck, Ebo D ...
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Catheterization ...
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