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The intrinsically p...
The intrinsically photosensitive retinal ganglion cell (ipRGC) mediated pupil response in young adult humans with refractive errors
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- Chakraborty, Ranjay (författare)
- Flinders University, Austria
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- Collins, Michael J. (författare)
- Queensland University of Technology, Australia
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- Kricancic, Henry (författare)
- Queensland University of Technology, Australia
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- Moderiano, Daniel (författare)
- Flinders University, Austria
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- Davis, Brett (författare)
- Queensland University of Technology, Australia
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- Alonso-Caneiro, David (författare)
- Queensland University of Technology, Australia
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- Yi, Fan (författare)
- Queensland University of Technology, Australia
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- Baskaran, Karthikeyan, Senior Lecturer, 1983- (författare)
- Linnéuniversitetet,Institutionen för medicin och optometri (MEO)
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Journal of Optometry. - : Elsevier. - 1888-4296. ; 15:2, s. 112-121
- Relaterad länk:
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https://doi.org/10.1...
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https://lnu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose The intrinsically photosensitive retinal ganglion cells (ipRGCs) signal environmental light, with axons projected to the midbrain that control pupil size and circadian rhythms. Post-illumination pupil response (PIPR), a sustained pupil constriction after short-wavelength light stimulation, is an indirect measure of ipRGC activity. Here, we measured the PIPR in young adults with various refractive errors using a custom-made optical system. Methods PIPR was measured on myopic (−3.50 ± 1.82 D, n = 20) and non-myopic (+0.28 ± 0.23 D, n = 19) participants (mean age, 23.36 ± 3.06 years). The right eye was dilated and presented with long-wavelength (red, 625 nm, 3.68 × 1014 photons/cm2/s) and short-wavelength (blue, 470 nm, 3.24 × 1014 photons/cm2/s) 1 s and 5 s pulses of light, and the consensual response was measured in the left eye for 60 s following light offset. The 6 s and 30 s PIPR and early and late area under the curve (AUC) for 1 and 5 s stimuli were calculated. Results For most subjects, the 6 s and 30 s PIPR were significantly lower (p < 0.001), and the early and late AUC were significantly larger for 1 s blue light compared to red light (p < 0.001), suggesting a strong ipRGC response. The 5 s blue stimulation induced a slightly stronger melanopsin response, compared to 1 s stimulation with the same wavelength. However, none of the PIPR metrics were different between myopes and non-myopes for either stimulus duration (p > 0.05). Conclusions We confirm previous research that there is no effect of refractive error on the PIPR.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Intrinsically photosensitive retinal ganglion cells
- Pupil
- Melanopsin
- Refractive error
- Myopia
- Optometry
- Optometri
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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