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The intracellular d...
The intracellular distribution of cobalt in exposed and unexposed rat myocardium
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Clyne, N (författare)
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- Persson, Bengt L. (författare)
- Department of Biochemistry, University of Stockholm
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Havu, N (författare)
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visa fler...
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Hultman, E (författare)
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Lins, L-E (författare)
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Pehrsson, S K (författare)
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Rydström, J (författare)
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Wibom, R (författare)
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visa färre...
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(creator_code:org_t)
- 1990
- 1990
- Engelska.
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Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - 0036-5513 .- 1502-7686. ; 50:6, s. 605-609
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS04-7 H20/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had the highest levels of cobalt. This could affect calcium flux in myocardial cells and, secondarily, tension development in cardiac muscle.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Biochemistry
- Biokemi
- Biochemistry
- Biokemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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