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Sökning: onr:"swepub:oai:DiVA.org:lnu-123579" > A Comparison of Hos...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007485naa a2200697 4500
001oai:DiVA.org:lnu-123579
003SwePub
008230810s2023 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-519125
009oai:gup.ub.gu.se/328336
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-1235792 URI
0247 a https://doi.org/10.1128/spectrum.02586-222 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5191252 URI
0247 a https://gup.ub.gu.se/publication/3283362 URI
040 a (SwePub)lnud (SwePub)uud (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Naguib, Mahmoudu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)mahna768
2451 0a A Comparison of Host Responses to Infection with Wild-Type Avian Influenza Viruses in Chickens and Tufted Ducks
264 1b American Society for Microbiology,c 2023
338 a print2 rdacarrier
520 a Cross-species transmission of influenza A virus (IAV) from wild waterfowl to poultry is the first step in a chain of events that can ultimately lead to exposure and infection of humans. Herein, we study the outcome of infection with eight different mallard-origin IAV subtypes in two different avian hosts: tufted ducks and chickens. We found that infection and shedding patterns as well as innate immune responses were highly dependent on viral subtypes, host species, and inoculation routes. For example, intraoesophageal inoculation, commonly used in mallard infection experiments, resulted in no infections in contrast to oculonasal inoculation, suggesting a difference in transmission routes. Despite H9N2 being endemic in chickens, inoculation of mallard-origin H9N2 failed to cause viable infection beyond 1 day postinfection in our study design. The innate immune responses were markedly different in chickens and tufted ducks, and despite the presence of retinoic acid-inducible gene-I (RIG-I) in tufted duck transcriptomes, it was neither up nor downregulated in response to infection. Overall, we have revealed the heterogeneity of infection patterns and responses in two markedly different avian hosts following a challenge with mallard-origin IAV. These virus-host interactions provide new insights into important aspects of interspecies transmission of IAV.IMPORTANCE Our current findings highlight important aspects of IAV infection in birds that have implications for our understanding of its zoonotic ecology. In contrast to mallards where the intestinal tract is the main site of IAV replication, chickens and tufted ducks show limited or no signs of intestinal infection suggesting that the fecal-oral transmission route might not apply to all bird IAV host species. Our results indicate that mallard-origin IAVs undergo genetic changes upon introduction into new hosts, suggesting rapid adaptation to a new environment. However, similar to the mallard, chickens and tufted ducks show a limited immune response to infection with low pathogenic avian influenza viruses. These findings and future studies in different IAV hosts are important for our understanding of barriers to IAV transmission between species and ultimately from the wild reservoir to humans. Our current findings highlight important aspects of IAV infection in birds that have implications for our understanding of its zoonotic ecology. In contrast to mallards where the intestinal tract is the main site of IAV replication, chickens and tufted ducks show limited or no signs of intestinal infection suggesting that the fecal-oral transmission route might not apply to all bird IAV host species.
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
653 a influenza virus
653 a gene expression
653 a innate immunity
653 a adaptive viral mutations
653 a Zoonotisk ekologi
653 a Zoonotic Ecology
653 a influenza virus
653 a gene expression
653 a innate immunity
653 a adaptive viral mutations
7001 a Eriksson, Peru Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)perer797
7001 a Jax, Elinoru Max Planck Inst Anim Behav, Germany;Univ Konstanz, Germany,Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell, Germany;Department of Biology, University of Konstanz, Konstanz, Germany4 aut
7001 a Wille, Michelleu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)micwi695
7001 a Lindskog, Ceciliau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin4 aut0 (Swepub:uu)cecli129
7001 a Bröjer, Carolineu Department of Pathology and Wildlife Diseases, National Veterinary Institute (SVA), Uppsala, Sweden4 aut
7001 a Krambrich, Janinau Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)jankr830
7001 a Waldenström, Jonas,d 1975-u Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden4 aut0 (Swepub:lnu)ewajo
7001 a Kraus, Robert H. S.u Max Planck Inst Anim Behav, Germany;Univ Konstanz, Germany,Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell, Germany;Department of Biology, University of Konstanz, Konstanz, Germany4 aut
7001 a Larson, Göran,d 1953u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine4 aut0 (Swepub:gu)xlarsg
7001 a Lundkvist, Åkeu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)akelu185
7001 a Olsen, Björnu Uppsala universitet,Infektionsmedicin4 aut0 (Swepub:uu)bjool781
7001 a Järhult, Josef D.,d 1975-u Uppsala universitet,Infektionsmedicin4 aut0 (Swepub:uu)josja939
7001 a Ellström, Patriku Uppsala universitet,Infektionsmedicin,Klinisk mikrobiologi4 aut0 (Swepub:uu)patel687
7102 a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org
7730 t Microbiology Spectrumd : American Society for Microbiologyg 11:4q 11:4x 2165-0497
8564 u https://doi.org/10.1128/spectrum.02586-22y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1823765/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-123579
8564 8u https://doi.org/10.1128/spectrum.02586-22
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-519125
8564 8u https://gup.ub.gu.se/publication/328336

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