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Sökning: onr:"swepub:oai:DiVA.org:lnu-125202" > Four additional nat...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004972naa a2200601 4500
001oai:DiVA.org:lnu-125202
003SwePub
008231019s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-1252022 URI
0247 a https://doi.org/10.1093/nar/gkad6572 DOI
040 a (SwePub)lnu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cui, Liangu Singapore MIT Alliance Res & Technol, Singapore4 aut
2451 0a Four additional natural 7-deazaguanine derivatives in phages and how to make them
264 1b Oxford University Press,c 2023
338 a print2 rdacarrier
520 a Bacteriophages and bacteria are engaged in a constant arms race, continually evolving new molecular tools to survive one another. To protect their genomic DNA from restriction enzymes, the most common bacterial defence systems, double-stranded DNA phages have evolved complex modifications that affect all four bases. This study focuses on modifications at position 7 of guanines. Eight derivatives of 7-deazaguanines were identified, including four previously unknown ones: 2 & PRIME;-deoxy-7-(methylamino)methyl-7-deazaguanine (mdPreQ(1)), 2 & PRIME;-deoxy-7-(formylamino)methyl-7-deazaguanine (fdPreQ(1)), 2 & PRIME;-deoxy-7-deazaguanine (dDG) and 2 & PRIME;-deoxy-7-carboxy-7-deazaguanine (dCDG). These modifications are inserted in DNA by a guanine transglycosylase named DpdA. Three subfamilies of DpdA had been previously characterized: bDpdA, DpdA1, and DpdA2. Two additional subfamilies were identified in this work: DpdA3, which allows for complete replacement of the guanines, and DpdA4, which is specific to archaeal viruses. Transglycosylases have now been identified in all phages and viruses carrying 7-deazaguanine modifications, indicating that the insertion of these modifications is a post-replication event. Three enzymes were predicted to be involved in the biosynthesis of these newly identified DNA modifications: 7-carboxy-7-deazaguanine decarboxylase (DpdL), dPreQ(1) formyltransferase (DpdN) and dPreQ(1) methyltransferase (DpdM), which was experimentally validated and harbors a unique fold not previously observed for nucleic acid methylases.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653 a Biokemi
653 a Biochemistry
653 a Mikrobiologi
653 a Microbiology
7001 a Balamkundu, Seetharamsingu Singapore MIT Alliance Res & Technol, Singapore;Nanyang Technol Univ, Singapore4 aut
7001 a Liu, Chuan-Fau Nanyang Technol Univ, Singapore4 aut
7001 a Ye, Hongu Nanyang Technol Univ, Singapore4 aut
7001 a Hourihan, Jacobu Univ Florida, USA4 aut
7001 a Rausch, Astridu Univ Florida, USA;Hirsch Apotheke Wollstein, Germany4 aut
7001 a Hauss, Christopheru Univ Florida, USA;Inst Pharmaceut Technol, Germany;Buchmann Inst Mol Life Sci, Germany4 aut
7001 a Nilsson, Emelieu Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS4 aut0 (Swepub:lnu)emniab
7001 a Hoetzinger, Matthiasu Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Norwegian Univ Life Sci, Norway,Ctr Ecol & Evolut Microbial Model Syst EEMiS4 aut
7001 a Holmfeldt, Karin,d 1980-u Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS4 aut0 (Swepub:lnu)mhoka
7001 a Zhang, Weijiau Univ Copenhagen, Denmark4 aut
7001 a Martinez-Alvarez, Laurau Univ Copenhagen, Denmark4 aut
7001 a Peng, Xuu Univ Copenhagen, Denmark4 aut
7001 a Tremblay, Deniseu Univ Laval, Canada4 aut
7001 a Moinau, Sylvainu Univ Laval, Canada4 aut
7001 a Solonenko, Natalieu Ohio State Univ, USA4 aut
7001 a Sullivan, Matthew B.u Ohio State Univ, USA4 aut
7001 a Lee, Yan-Jiunu New England Biolabs Inc, USA4 aut
7001 a Mulholland, Andrewu New England Biolabs Inc, USA4 aut
7001 a Weigele, Peter R.u New England Biolabs Inc, USA4 aut
7001 a de Crecy-Lagard, Valerieu Univ Florida, USA4 aut
7001 a Dedon, Peter C.u Singapore MIT Alliance Res & Technol, Singapore;MIT, USA4 aut
7001 a Hutinet, Geoffreyu Univ Florida, USA4 aut
7102 a Singapore MIT Alliance Res & Technol, Singaporeb Singapore MIT Alliance Res & Technol, Singapore;Nanyang Technol Univ, Singapore4 org
7730 t Nucleic Acids Researchd : Oxford University Pressg 51:17, s. 9214-9226q 51:17<9214-9226x 0305-1048x 1362-4962
8564 u https://doi.org/10.1093/nar/gkad657y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-125202
8564 8u https://doi.org/10.1093/nar/gkad657

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