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Sökning: onr:"swepub:oai:DiVA.org:lnu-1914" > Phylogenetic analys...

  • Zohari, Siamak (författare)

Phylogenetic analysis of the non-structural (NS) gene of influenza A viruses isolated from mallards in Northern Europe in 2005

  • Artikel/kapitelEngelska2008

Förlag, utgivningsår, omfång ...

  • 2008
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:lnu-1914
  • https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-1914URI
  • https://doi.org/10.1186/1743-422X-5-147DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-88440URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Although the important role of the non-structural 1 (NS) gene of influenza A in virulence of the virus is well established, our knowledge about the extent of variation in the NS gene pool of influenza A viruses in their natural reservoirs in Europe is incomplete. In this study we determined the subtypes and prevalence of influenza A viruses present in mallards in Northern Europe and further analysed the NS gene of these isolates in order to obtain a more detailed knowledge about the genetic variation of NS gene of influenza A virus in their natural hosts. Results: A total number of 45 influenza A viruses of different subtypes were studied. Eleven haemagglutinin-and nine neuraminidase subtypes in twelve combinations were found among the isolated viruses. Each NS gene reported here consisted of 890 nucleotides; there were no deletions or insertions. Phylogenetic analysis clearly shows that two distinct gene pools, corresponding to both NS allele A and B, were present at the same time in the same geographic location in the mallard populations in Northern Europe. A comparison of nucleotide sequences of isolated viruses revealed a substantial number of silent mutations, which results in high degree of homology in amino acid sequences. The degree of variation within the alleles is very low. In our study allele A viruses displays a maximum of 5% amino acid divergence while allele B viruses display only 2% amino acid divergence. All the viruses isolated from mallards in Northern Europe possessed the typical avian ESEV amino acid sequence at the C-terminal end of the NSI protein. Conclusion: Our finding indicates the existence of a large reservoir of different influenza A viruses in mallards population in Northern Europe. Although our phylogenetic analysis clearly shows that two distinct gene pools, corresponding to both NS allele A and B, were present in the mallards populations in Northern Europe, allele B viruses appear to be less common in natural host species than allele A, comprising only about 13% of the isolates sequenced in this study.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gyarmati, P. (författare)
  • Ejdersund, A. (författare)
  • Berglöf, U. (författare)
  • Thorén, P. (författare)
  • Ehrenberg, M. (författare)
  • Czifra, G. (författare)
  • Belak, S. (författare)
  • Waldenström, JonasUppsala universitet,Högskolan i Kalmar,Naturvetenskapliga institutionen,Infektionssjukdomar(Swepub:lnu)ewajo (författare)
  • Olsen, BjörnUppsala universitet,Högskolan i Kalmar,Naturvetenskapliga institutionen,Infektionssjukdomar(Swepub:uu)bjool781 (författare)
  • Berg, M. (författare)
  • Högskolan i KalmarNaturvetenskapliga institutionen (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Virology Journal5:Article ID: 1471743-422X

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