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High serum CXCL10 i...
High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation.
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- Otterdal, Kari (författare)
- Oslo University Hospital Rikshospitalet, Norway
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- Portillo, Aránzazu (författare)
- Hospital San Pedro-Center of Biomedical Research from La Rioja (CIBIR), Spain
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- Astrup, Elisabeth (författare)
- Oslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway
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- Ludviksen, Judith (författare)
- Research Laboratory Nordland Hospital, Norway
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- Davì, Giovanni (författare)
- University of Chieti, Italy
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- Holm, Sverre (författare)
- Oslo University Hospital Rikshospitalet, Norway ; Hospital for Rheumatic Diseases, Norway
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- Santilli, Francesca (författare)
- University of Chieti, Italy
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- Vitale, Giustina (författare)
- University of Palermo, Italy
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- Raoult, Didier (författare)
- Université de la Mediterranée, France
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- Olano, Juan P (författare)
- University of Texas Medical Branch, USA
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- Schjalm, Camilla (författare)
- University of Oslo, Norway ; Oslo University Hospital Rikshospitalet, Norway
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- Halvorsen, Bente (författare)
- Oslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway
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- Oteo, José A (författare)
- Hospital San Pedro-Center of Biomedical Research from La Rioja (CIBIR), Spain
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- Mollnes, Tom Eirik (författare)
- University of Oslo, Norway ; Research Laboratory Nordland Hospital, Norway ; Oslo University Hospital Rikshospitalet, Norway ; University of Tromsø, Norway ; Norwegian University of Science and Technology, Norway
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- Aukrust, Pål (författare)
- Oslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway
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- Nilsson, Per H., 1980- (författare)
- Oslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Cytokine. - : Elsevier BV. - 1043-4666 .- 1096-0023. ; 83, s. 269-274
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The pathophysiological hallmark of Rickettsia conorii (R. conorii) infection comprises infection of endothelial cells with perivascular infiltration of T-cells and macrophages. Although interferon (IFN)-γ-induced protein 10 (IP-10)/CXCL10 is induced during vascular inflammation, data on CXCL10 in R. conorii infection is scarce.METHODS: Serum CXCL10 was analyzed in two cohorts of southern European patients with R. conorii infection using multiplex cytokine assays. The mechanism of R. conorii-induced CXCL10 release was examined ex vivo using human whole blood interacting with endothelial cells.RESULTS: (i) At admission, R. conorii infected patients had excessively increased CXCL10 levels, similar in the Italian (n=32, ∼56-fold increase vs controls) and the Spanish cohort (n=38, ∼68-fold increase vs controls), followed by a marked decrease after recovery. The massive CXCL10 increase was selective since it was not accompanied with similar changes in other cytokines. (ii) Heat-inactivated R. conorii induced a marked CXCL10 increase when whole blood and endothelial cells were co-cultured. Even plasma obtained from R. conorii-exposed whole blood induced a marked CXCL10 release from endothelial cells, comparable to the levels found in serum of R. conorii-infected patients. Bacteria alone did not induce CXCL10 production in endothelial cells, macrophages or smooth muscle cells.CONCLUSIONS: We show a massive and selective serum CXCL10 response in R. conorii-infected patients, likely reflecting release from infected endothelial cells characterized by infiltrating T cells and monocytes. The CXCL10 response could contribute to T-cell infiltration within the infected organ, but the pathologic consequences of CXCL10 in clinical R. conorii infection remain to be defined.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Immunologi
- Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Cytokine
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Otterdal, Kari
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Portillo, Aránza ...
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Astrup, Elisabet ...
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Ludviksen, Judit ...
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Davì, Giovanni
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Holm, Sverre
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Santilli, France ...
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Vitale, Giustina
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Raoult, Didier
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Olano, Juan P
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Schjalm, Camilla
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Halvorsen, Bente
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Oteo, José A
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Mollnes, Tom Eir ...
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Aukrust, Pål
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Nilsson, Per H., ...
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