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Directly measured f...
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Carlsson, MartinLinnéuniversitetet,Institutionen för medicin och optometri (MEO),Kalmar County Hospital, Sweden,Cty Hosp Kalmar, Sweden; Linnaeus Univ, Sweden
(författare)
Directly measured free 25-hydroxy vitamin D levels show no evidence of vitamin D deficiency in young Swedish women with anorexia nervosa
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2017-04-28
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Springer,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:lnu-72685
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https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-72685URI
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https://doi.org/10.1007/s40519-017-0392-yDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-147401URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|Medical Research Council of Southeast Sweden (FORSS)
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Purpose Anorexia nervosa (AN) is an eating disorder characterized by low fat mass complicated by osteoporosis. The role of circulating vitamin D in the development of bone loss in AN is unclear. Fat mass is known to be inversely associated with vitamin D levels measured as serum levels of total, protein-bound 25-hydroxyvitamin D, but the importance of directly measured, free levels of 25(OH)D has not been determined in AN. The aim of this study was to investigate vitamin D status, as assessed by serum concentrations of total and free serum 25(OH)D in patients with AN and healthy controls. Methods In female AN patients (n = 20), and healthy female controls (n = 78), total 25(OH)D was measured by LC-MS/MS, and free 25(OH)D with ELISA. In patients with AN bone mineral density (BMD) was determined with DEXA. Results There were no differences between patients and controls in total or free S-25(OH)D levels (80 +/- 31 vs 72 +/- 18 nmol/L, and 6.5 +/- 2.5 vs 5.6 +/- 1.8 pg/ml, respectively), and no association to BMD was found. In the entire group of patients and controls, both vitamin D parameters correlated with BMI, leptin, and PTH. Conclusions The current study did not demonstrate a vitamin D deficiency in patients with AN and our data does not support vitamin D deficiency as a contributing factor to bone loss in AN. Instead, we observed a trend toward higher vitamin D levels in AN subjects compared to controls. Measurement of free vitamin D levels did not contribute to additional information.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Brudin, LarsLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Cty Hosp Kalmar, Sweden(Swepub:liu)larbr27
(författare)
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Wanby, PärKalmar County Hospital, Sweden,Cty Hosp Kalmar, Sweden(Swepub:lnu)pawaab
(författare)
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LinnéuniversitetetInstitutionen för medicin och optometri (MEO)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Eating and Weight Disorders: Springer23:2, s. 247-2541124-49091590-1262
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