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Effects of amrinone...
Effects of amrinone on the electromechanical coupling in frog skeletal muscle fibres
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Mörner, J (författare)
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- Månsson, Alf (författare)
- Department of Pharmacology, University of Lund
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(creator_code:org_t)
- Wiley, 1990
- 1990
- Engelska.
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Ingår i: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 139, s. 289-295
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The contractile effects of I.I mM amrinone were studied on isolated skeletal muscle fibres of the frog (2–5 °C, slack length). Amrinone potentiated the twitch amplitude and the maximum tetanic tension and also enhanced the maximum contracture response elicited by 117.5 mM K+ (mean increase 6.3 ± 1.8 %, n = 6, P < 0.02). The time to halfrelaxation of the potassium contracture was slightly increased (mean change 13.8 ± 3.5%, n = 7, P < 0.01). Amrinone furthermore shifted the S-shaped curve relating contracture tension to log K+ to the left, and thus reduced the threshold depolarization (the mechanical threshold needed) to elicit a contracture (mean reduction 11 ± 1 mV). The duration of the action potential at the –25 mV level was slightly increased by amrinone, whereas the resting membrane potential was unaffected.
Nyckelord
- MEDICINE
- MEDICIN
- Biomedicinsk vetenskap
- Biomedical Sciences
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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